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首页> 外文期刊>Comparative Medicine >The Spatial Learning Phenotype of Heterozygous Leaner Mice is Robust to Systematic Variation of the Housing Environment
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The Spatial Learning Phenotype of Heterozygous Leaner Mice is Robust to Systematic Variation of the Housing Environment

机译：杂合性贫小鼠的空间学习表型对住房环境的系统变化具有鲁棒性

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Providingstimulationandallowingtheperformanceofmotivatedbehaviorsthroughenvironmentalenrichmentimproveslearningandmemoryinrodentsanddelayscognitiveimpairmentinneurodegenerativediseasemodels.TheleanermutationaffectstheCasubxmlns="http://pub2web.metastore.ingenta.coms/"v/sub2.1voltage-gatedcalciumchannel#945;subxmlns="http://pub2web.metastore.ingenta.coms/"1A/sub-subunitgene,andhomozygousmiceshowseverephenotypicalterations.Althoughseveralauthorshavedescribedheterozygousmiceasnormal,recentstudiesinourlaboratoryindicatemotorandcognitiveimpairmentintgsupla/sup/+mice.Inthepresentstudy,weevaluatedwhetherthisimpairmentisrobusttosystematicvariationofthehousingenvironmentfrombarrentostandardandfurnished(enriched)cages.Wildtype(n=55)andtgsupla/sup/+(n=79)C57Bl/6Jmicewereassignedrandomlyto1ofthe3housingsystemsandtestedontheMorriswatermazeat6,12,and20moofage.Theresultsconfirmedimpairedperformanceintgsupla/sup/+mice,particularlyinoldermice.At12and20mo,onlywildtype(andnottgsupla/sup/+)miceshowedevidenceoflearning(spendingincreasedtimeinthetargetquadrant)duringtheprobetrial.Housingalsoaffectedperformance:at12mo,onlymicefromfurnishedcagesshowedevidenceoflearning,andinagedmice(20mo),onlythosehousedinmorecomplexenvironmentsshowedlong-termmemory(8moafterprevioustesting)oftheplatformposition.Inconclusion,aheterozygousmutationinaCasupxmlns="http://pub2web.metastore.ingenta.coms/"2+/supchannelgenecausescognitivedeficitsinleanermicethatarerobusttoenvironmentalvariationbutattenuatedbyphysicalandbehavioralstimulation.
机译：通过环境退化来提供刺激并允许有动机的行为的表现改善神经衰弱疾病模型中的学习和记忆性啮齿动物和迟钝的认知损害。 / NS /“> 1A -subunitgene，andhomozygousmiceshowseverephenotypicalterations.Althoughseveralauthorshavedescribedheterozygousmiceasnormal，recentstudiesinourlaboratoryindicatemotorandcognitiveimpairmentintg LA / + mice.Inthepresentstudy，weevaluatedwhetherthisimpairmentisrobusttosystematicvariationofthehousingenvironmentfrombarrentostandardandfurnished（富集的）cages.Wildtype（N = 55）andtg LA < / sup> / +（n = 79）C57Bl / 6Jmice随机分配给3个住房系统中的1个，并在Morriswater绞肉上测试了6、12和20的移动性。结果证实，性能不佳的小鼠 la / +，特别是只有幼稚的老鼠，至少有（12和20型）。 la / +）小鼠在学习期间显示出学习的证据（在目标象限上花费的时间增加）。 ingenta.coms /“> 2 + 通道基因在较瘦的小鼠中引起认知缺陷，这些缺陷对环境变化具有稳健的作用，但会受到物理动物行为的刺激而减弱。

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