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首页> 外文期刊>Comparative Medicine >The spatial learning phenotype of heterozygous leaner mice is robust to systematic variation of the housing environment
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The spatial learning phenotype of heterozygous leaner mice is robust to systematic variation of the housing environment

机译：杂合性瘦小鼠的空间学习表型对住房环境的系统变化具有鲁棒性。

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Providing stimulation and allowing the performance of motivated behaviors through environmental enrichment improves learning and memory in rodents and delays cognitive impairment in neurodegenerative disease models. The leaner mutation affects the Ca(v)2.1 voltage-gated calcium channel alpha(1A)-subunit gene, and homozygous mice show severe phenotypic alterations. Although several authors have described heterozygous mice as normal, recent studies in our laboratory indicate motor and cognitive impairment in tg(la)/+ mice. In the present study, we evaluated whether this impairment is robust to systematic variation of the housing environment from barren to standard and furnished (enriched) cages. Wildtype (n = 55) and tg(la)/+ (n = 79) C57Bl/6J mice were assigned randomly to 1 of the 3 housing systems and tested on the Morris water maze at 6, 12, and 20 mo of age. The results confirmed impaired performance in tg(la)/+ mice, particularly in older mice. At 12 and 20 mo, only wildtype (and not tg(la)/+) mice showed evidence of learning (spending increased time in the target quadrant) during the probe trial. Housing also affected performance: at 12 mo, only mice from furnished cages showed evidence of learning, and in aged mice (20 mo), only those housed in more complex environments showed long-term memory (8 mo after previous testing) of the platform position. In conclusion, a heterozygous mutation in a Ca(2+) channel gene causes cognitive deficits in leaner mice that are robust to environmental variation but attenuated by physical and behavioral stimulation.
机译：通过环境充实提供刺激并允许表现出积极的行为，可以提高啮齿动物的学习和记忆能力，并延迟神经退行性疾病模型中的认知障碍。更瘦的突变影响Ca（v）2.1电压门控钙通道alpha（1A）-亚基基因，纯合小鼠显示严重的表型改变。尽管有几位作者将杂合小鼠描述为正常小鼠，但我们实验室的最新研究表明tg（la）/ +小鼠存在运动和认知障碍。在本研究中，我们评估了这种损害是否对从贫瘠的到标准的和带家具的（丰富的）笼子的住房环境的系统变化具有鲁棒性。将野生型（n = 55）和tg（la）/ +（n = 79）C57Bl / 6J小鼠随机分配至3个住房系统中的1个，并在6、12和20 mo龄的莫里斯水迷宫中进行测试。结果证实了在tg（la）/ +小鼠中的性能受损，尤其是在老年小鼠中。在12和20 mo时，只有野生型（而非tg（la）/ +）小鼠在探针试验期间显示出学习的证据（在目标象限中花费的时间增加）。住房也影响了性能：在12个月时，只有带家具的笼子中的小鼠显示出学习的证据，而在老年小鼠（20个月）中，只有那些居住在更复杂环境中的小鼠才表现出平台的长期记忆（先前测试后为8个月）。位置。总之，在Ca（2+）通道基因中的杂合突变会导致较瘦小鼠的认知缺陷，该缺陷对环境变化具有稳健性，但会受到身体和行为刺激的影响而减弱。

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