Temporal Changes of Angiopoietins and Tie2 Expression in Rat Lungs after Monocrotaline-Induced Pulmonary Hypertension

Cho Yu Ji; Han Jae Yoon; Lee Sang Gab; Jeon Byeong Tak; Choi Wan Sung; Hwang Young Sil; Roh Gu Seob; Lee Jong Deog

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Temporal Changes of Angiopoietins and Tie2 Expression in Rat Lungs after Monocrotaline-Induced Pulmonary Hypertension

机译：苦瓜碱诱导的肺动脉高压后大鼠肺血管生成素和Tie2表达的时间变化

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Angiogenicfactorssuchasvascularendothelialgrowthfactor(VEGF)areimplicatedinpulmonaryhypertension(PH).However,thepathwayofangiogenicfactor-mediatedpathologicangiogenesisinPHremainsunclear.Inthisstudy,weevaluatedthetemporalexpressionofangiopoietin(Ang)1,Ang2,andtheirreceptor(Tie2)aswellasVEGF,endothelialnitricoxidesynthase(eNOS),inducibleNOS(iNOS),andhemeoxygenase1(HO1)inthemonocrotaline-inducedPHmodel.Histologicevaluationshowedpathologicvascularremodelinginthearteriesoflungsections1wkaftermonocrotalinetreatment.ProteinlevelsofAng1,Ang2,eNOS,iNOS,HO1,andVEGFwereincreased1wkaftermonocrotalinetreatmentbutTie2proteinlevelsweredecreased2wkafterward.TheseresultssuggestthatAng2mediatesvascularremodelinginPHbydecreasingTie2expression.Therefore,theAng#8211;Tie2systemmayplayaroleinthepathophysiologyofPH.

机译：Angiogenicfactorssuchasvascularendothelialgrowthfactor（VEGF）areimplicatedinpulmonaryhypertension（PH）。然而，thepathwayofangiogenicfactor-mediatedpathologicangiogenesisinPHremainsunclear.Inthisstudy，weevaluatedthetemporalexpressionofangiopoietin（ANG）1，Ang2的，andtheirreceptor（Tie2的）aswellasVEGF，endothelialnitricoxidesynthase型（eNOS），inducibleNOS（iNOS）的，andhemeoxygenase1（HO1）inthemonocrotaline-inducedPHmodel.Histologicevaluationshowedpathologicvascularremodelinginthearteriesoflungsections1wkaftermonocrotalinetreatment单crotaline处理后，蛋白Ang1，Ang2，eNOS，iNOS，HO1和VEGF的蛋白水平增加了1周，但随后Tie2蛋白的水平却降低了2w。

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《Comparative Medicine》 |2009年第4期|共页
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Cho Yu Ji; Han Jae Yoon; Lee Sang Gab; Jeon Byeong Tak; Choi Wan Sung; Hwang Young Sil; Roh Gu Seob; Lee Jong Deog;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension [J] . Cho YJ, Han JY, Lee SG, Comparative Medicine . 2009,第4期

机译：克豆肾上腺素诱发的肺动脉高压后大鼠肺中血管生成素和Tie2表达的时间变化。
2. Changes of Pulmonary Pathology and Gene Expressions After Simvastatin Treatment in the Monocrotaline-Induced Pulmonary Hypertension Rat Model [J] . Lee Yun Hee, Kim Kwan Chang, Cho Min-Sun, Korean Circulation Journal . 2011,第9期

机译：辛伐他汀引起的吗啉他汀诱导的肺动脉高压大鼠模型中肺病理学和基因表达的变化
3. Downregulation of angiopoietin-1 and Tie2 in chronic hypoxic pulmonary hypertension. [J] . Yamamoto A, Takahashi H, Kojima Y, Respiration: International Review of Thoracic Diseases . 2008,第3期

机译：慢性低氧性肺动脉高压中血管生成素-1和Tie2的下调。
4. Treatment with LA-419 Prevents Monocrotaline-Induced Pulmonary Hypertension and Lung Injury in the Rat [C] . Mourelle M., Martin M.T Gimenez F. Western Pharmacology Society . 2011

机译：用LA-419治疗可防止大鼠肺动脉高压和大鼠肺损伤
5. Pulmonary disease in scleroderma: Combined interstitial lung disease and pulmonary hypertension and predictors of pulmonary hypertension. [D] . Chang, Betty. 2003

机译：硬皮病中的肺部疾病：间质性肺部疾病和肺动脉高压的结合以及肺动脉高压的预测因子。
6. Temporal Changes of Angiopoietins and Tie2 Expression in Rat Lungs after Monocrotaline-Induced Pulmonary Hypertension [O] . Yu Ji Cho, Jae Yoon Han, Sang Gab Lee, 2009

机译：苦瓜碱致肺动脉高压后大鼠肺血管生成素和Tie2表达的时空变化
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Temporal Changes of Angiopoietins and Tie2 Expression in Rat Lungs after Monocrotaline-Induced Pulmonary Hypertension

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