Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension

Cho YJ; Han JY; Lee SG; Jeon BT; Choi WS; Hwang YS; Roh GS; Lee JD

首页> 外文期刊>Comparative Medicine >Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension

【24h】

Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension

机译：克豆肾上腺素诱发的肺动脉高压后大鼠肺中血管生成素和Tie2表达的时间变化。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Angiogenic factors such as vascular endothelial growth factor (VEGF) are implicated in pulmonary hypertension (PH). However, the pathway of angiogenic factor-mediated pathologic angiogenesis in PH remains unclear. In this study, we evaluated the temporal expression of angiopoietin (Ang) 1, Ang2, and their receptor (Tie2) as well as VEGF, endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), and heme oxygenase 1 (HO1) in the monocrotaline-induced PH model. Histologic evaluation showed pathologic vascular remodeling in the arteries of lung sections 1 wk after monocrotaline treatment. Protein levels of Ang1, Ang2, eNOS, iNOS, HO1, and VEGF were increased 1 wk after monocrotaline treatment but Tie2 protein levels were decreased 2 wk afterward. These results suggest that Ang2 mediates vascular remodeling in PH by decreasing Tie2 expression. Therefore, the Ang-Tie2 system may play a role in the pathophysiology of PH.

机译：血管生成因子，例如血管内皮生长因子（VEGF）与肺动脉高压（PH）有关。然而，PH中血管生成因子介导的病理性血管生成的途径仍不清楚。在这项研究中，我们评估了血管生成素（Ang）1，Ang2及其受体（Tie2）以及VEGF，内皮型一氧化氮合酶（eNOS），诱导型NOS（iNOS）和血红素加氧酶1（HO1）的时间表达。在单芥子碱诱导的PH模型中。组织学评估显示，在单肾上腺素治疗后1周，肺部动脉的病理性血管重塑。单crocrotaline处理后1周，Ang1，Ang2，eNOS，iNOS，HO1和VEGF的蛋白水平升高，但随后2周，Tie2蛋白水平降低。这些结果表明Ang2通过降低Tie2表达来介导PH的血管重塑。因此，Ang-Tie2系统可能在PH的病理生理中起作用。

著录项

来源
《Comparative Medicine》 |2009年第4期|共7页
作者
Cho YJ; Han JY; Lee SG; Jeon BT; Choi WS; Hwang YS; Roh GS; Lee JD;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类畜牧、动物医学、狩猎、蚕、蜂;
关键词

相似文献

外文文献
中文文献
专利

1. Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension [J] . Cho YJ, Han JY, Lee SG, Comparative Medicine . 2009,第4期

机译：克豆肾上腺素诱发的肺动脉高压后大鼠肺中血管生成素和Tie2表达的时间变化。
2. Changes of Pulmonary Pathology and Gene Expressions After Simvastatin Treatment in the Monocrotaline-Induced Pulmonary Hypertension Rat Model [J] . Lee Yun Hee, Kim Kwan Chang, Cho Min-Sun, Korean Circulation Journal . 2011,第9期

机译：辛伐他汀引起的吗啉他汀诱导的肺动脉高压大鼠模型中肺病理学和基因表达的变化
3. Downregulation of angiopoietin-1 and Tie2 in chronic hypoxic pulmonary hypertension. [J] . Yamamoto A, Takahashi H, Kojima Y, Respiration: International Review of Thoracic Diseases . 2008,第3期

机译：慢性低氧性肺动脉高压中血管生成素-1和Tie2的下调。
4. Treatment with LA-419 Prevents Monocrotaline-Induced Pulmonary Hypertension and Lung Injury in the Rat [C] . Mourelle M., Martin M.T Gimenez F. Western Pharmacology Society . 2011

机译：用LA-419治疗可防止大鼠肺动脉高压和大鼠肺损伤
5. Pulmonary disease in scleroderma: Combined interstitial lung disease and pulmonary hypertension and predictors of pulmonary hypertension. [D] . Chang, Betty. 2003

机译：硬皮病中的肺部疾病：间质性肺部疾病和肺动脉高压的结合以及肺动脉高压的预测因子。
6. Temporal Changes of Angiopoietins and Tie2 Expression in Rat Lungs after Monocrotaline-Induced Pulmonary Hypertension [O] . Yu Ji Cho, Jae Yoon Han, Sang Gab Lee, 2009

机译：苦瓜碱致肺动脉高压后大鼠肺血管生成素和Tie2表达的时空变化
7. HIT Poster session 1P154Preclinical diastolic dysfunction is related to impaired endothelial function in patients with chronic kidney diseaseP155Early detection of left atrial and left ventricular abnormalities in hypertensive and obese womenP156Right ventricle preserved systolic function irrespective of right ventricular hypertrophy and disease severity in anderson fabry diseaseP157Left atrial volume and function in patients undergoing percutaneous mitral valve repairP158Impact of left ventricular dysfunction on outcomes of patients undergoing direct TAVI with a self-expanding bioprosthesisP159Anatomic Doppler spectrum – retrospective spectral tissue Doppler from ultra high frame rate tissue Doppler imaging for evaluation of tissue deformationP160Phasic dynamics of ischaemic mitral regurgitation after primary coronary intervention in acute myocardial infarction: serial echocardiographic assessment from emergency room to long-term follow-upP161Reproducibility of 3DE RV volumes - novel insights at a regional levelP162Pulmonary vascular capacitance as assessed by echocardiography in pulmonary arterial hypertensionP163Three-dimensional endocardial area strain: a novel parameter for quantitative assessment of global left ventricular systolic functionP164Role of exercise hemodynamics assessed by echocardiography on symptom reduction after MitraClipP165Early identification of ventricular dysfunction in patients with juvenile systemic sclerosisP166Heart failure with and without preserved ejection fraction - the role of biomarkers in the aspect of global longitudinal strainP167Complex systolic deformation of aortic root: insights from two dimensional speckle tracking imageP168Volumetric and deformational imaging usind 2d strain and 3d echocardiography in patients with pulmonary hypertensionP169Influence of pressure load and right ventricular morphology and function on tricuspid regurgitation in pulmonary arterial hypertensionP170Left ventricular myocardial diastolic deformation analysis by 2D speckle tracking echocardiography and relationship with conventional diastolic parameters in chronic aortic regurgitationP171Extracellular volume, and not native T1 time, distinguishes diffuse fibrosis in dilated or hypertrophic cardiomyopathy at 3TP172Left atrial strain is significantly reduced in arterial hypertensionP173Symptomatic severe secondary mitral regurgitation: LV enddiastolic diameter (LVEDD) as preferable parameter for risk stratificationP174Left ventricular mechanics in isolated left bundle branch block at rest and when exercising: exploration of the concept of conductive cardiomyopathyP175Assessment of myocardial scar by 2D contrast echocardiographyP176Chronic pericarditis - expression of a rare disease: Erdheim Chester diseaseP177Aortic arch mechanics with two-dimensional speckle tracking echocardiography to estimate the left ventricular remodelling in hypertensive patientsP178Strain analysis by tissue doppler imaging: comparison of conventional manual measurement with a semi-automated approachP179Distribution of extravascular lung water in heart failure patients assessed by lung ultrasoudP180Surrogate markers for obstructive coronary artery diseaseP181LA deformation and LV longitudinal strain by two-dimensional speckle tracking echocardiography as predictors of postoperative AF development after aortic valve replacement in ASP182Left ventricular diastolic dysfunction in type 2 diabetic patients with non alcoholic fatty liver diseaseP183Myocardial strain by speckle-tracking and evaluation of 3D ejection fraction in drug-induced cardiotoxicity's approach in breast cancer [O] . AB Gevaert, A Borizanova, F Graziani, 2015

机译：HIT墙报1P154Preclinical舒张功能障碍的慢性肾脏diseaseP155Early检测左心房的相关内皮功能受损，左心室异常，高血压和肥胖womenP156Right心室收缩功能正常，不论右心室肥厚和疾病严重程度在安德森法布里diseaseP157Left房容积和经皮二尖瓣修复患者的功能左心室功能障碍与自膨胀生物升降术患者患者患者的结果，来自超高帧速率组织多普勒成像的患者，用于评估缺血二尖瓣复发的组织变形P160平面动力学后在急性心肌梗死冠脉介入干预：从急诊室到三维超声心动图右心室体积的长期跟踪upP161Reproducibility串行超声心动图评价 - 小说由肺动脉高压肺动脉高压术中超声心动图评估的区域SEATP162玻璃血管电容的见解随着少年全身硬化肺源肌腱肌肤，无需保存的射血分数 - 生物标志物在全球纵向菌株的角色在全球纵向菌株P167比分中的一个主动脉根系中的内容：来自二维散斑跟踪Imagep168散热和变形成像的见解，肺高压患者患者患者患者肺动脉高压患者肺动脉高压肺动脉高压术治疗肺动脉高压术治疗的压力载荷和右心室形态和功能通过2D散斑跟踪超声心动图和与常规舒张性参数的关系分析慢性主动脉率高，而不是天然T1的时间，在3TP172LEFT心房菌株中区分扩张或肥厚性心肌病的扩散纤维化在动脉高压症中显着降低了，在动脉高压症P1173例，严重二次二尖瓣重新改善：LV EndDiaal直径（LVEDD）作为休息左侧束分支块中孤立的左束分支块的风险分层P11744444444444444445的概念：探讨了2D对比超声心动图176Chronic心包炎的心肌瘢痕的导电心肌病概念 - 表达罕见具有二维散斑跟踪超声心动图的力学来估算组织多普勒成像的高血压患者左心室重塑：常规人的比较通过半自动方法测量肺血管肺患者肺血管肺水分分布，由肺超声波180surrogalsp181LA变形和LV纵向应变通过二维散斑跟踪超声心动图作为术后AF的预测因子在ASP182LEFT中更换主动脉瓣膜置换后2型糖尿病患者的心室舒张功能障碍非酒精性脂肪肝病患者P183微囊菌株通过斑点跟踪和评估3D乳腺癌中的3D射血分数的评估

Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension

摘要

著录项

相似文献

相关主题

期刊订阅