Prevalence and Diagnosis of Hemotrophic Mycoplasma Infection in Research Sheep and Its Effects on Hematology Variables and Erythrocyte Membrane Fragility

Hampel Joseph A; Spath Samantha N; Bergin Ingrid L; Lim Ailam; Bolin Steven R; Dyson Melissa C

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Prevalence and Diagnosis of Hemotrophic Mycoplasma Infection in Research Sheep and Its Effects on Hematology Variables and Erythrocyte Membrane Fragility

机译：研究绵羊中嗜血支原体感染的流行，诊断及其对血液学变量和红细胞膜脆性的影响

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Hemotrophicmycoplasma(hemoplasma)infectioninresearchsheepcanconfoundexperimentalresultsandcontributetomorbidityandmortality.Prevalenceandclinicopathologicstudieshistoricallyreliedonblood-smeardiagnosis,butsystematicstudiesusingcurrentmoleculartechniquesarewarranted.Herewesoughttoreporttheprevalenceofsubclinicalinfectioninourstudypopulation,comparediagnosticsensitivityandspecificitybetweenbloodsmearsandaPCRassay,anddeterminetheeffectsofinfectiononCBCvariablesanderythrocytemembranefragility.Wecollectedwhole-bloodsamplesfrom111convenience-sampledresearchsheep.AllsamplesweretestedforhemoplasmasbyusingaPCRassay,bloodsmearswereevaluatedforvisualpresenceofhemoplasmas,andCBCandosmoticfragilityassayswereperformed.Subclinicalprevalence,accordingtoPCRdiagnosis,was14.1%(14of99)inourstudypopulation.RelativetothePCRassay,blood-smeardiagnosiswas8.3%sensitiveand100%specificforhemoplasmadetection.SubclinicalinfectionwasassociatedwithchangesinMCV,MCHC,RBCdistributionwidth,andabsolutemonocytecount.AcuteinfectionwasassociatedwithchangesinRBCmass,Hgbconcentration,MCV,MCH,MCHC,andabsolutelymphocyteandmonocytecounts.Acuteinfectionwasassociatedwithincreasedmeanerythrocytefragilitycomparedwiththatinuninfectedcontrolandtreatedsheep.Wedemonstratedthathemoplasmainfectioniscommoninourstudypopulation,blood-smearevaluationisinsensitiveatdetectinginfection,andinfectionisassociatedwithchangesinCBCvariablesandincreasederythrocytemembranefragility.Thesefindingsraiseconcernsregardingthesuitabilityofhemoplasma-infectedsheepforbiomedicalresearch.

机译：Hemotrophicmycoplasma（hemoplasma）infectioninresearchsheepcanconfoundexperimentalresultsandcontributetomorbidityandmortality.Prevalenceandclinicopathologicstudieshistoricallyreliedonblood-smeardiagnosis，butsystematicstudiesusingcurrentmoleculartechniquesarewarranted.Herewesoughttoreporttheprevalenceofsubclinicalinfectioninourstudypopulation，comparediagnosticsensitivityandspecificitybetweenbloodsmearsandaPCRassay，anddeterminetheeffectsofinfectiononCBCvariablesanderythrocytemembranefragility.Wecollectedwhole-bloodsamplesfrom111convenience-sampledresearchsheep.AllsamplesweretestedforhemoplasmasbyusingaPCRassay，bloodsmearswereevaluatedforvisualpresenceofhemoplasmas，andCBCandosmoticfragilityassayswereperformed.Subclinicalprevalence，accordingtoPCRdiagnosis，was14.1％（14of99）inourstudypopulation.RelativetothePCRassay，血液 - smeardiagnosiswas8.3亚临床感染与MCV，MCHC，RBC分布宽度，单核细胞计数改变有关。 nfectionwasassociatedwithchangesinRBCmass，Hgbconcentration，MCV，MCH，MCHC，andabsolutelymphocyteandmonocytecounts.Acuteinfectionwasassociatedwithincreasedmeanerythrocytefragilitycomparedwiththatinuninfectedcontrolandtreatedsheep.Wedemonstratedthathemoplasmainfectioniscommoninourstudypopulation，血smearevaluationisinsensitiveatdetectinginfection，andinfectionisassociatedwithchangesinCBCvariablesandincreasederythrocytemembranefragility.Thesefindingsraiseconcernsregardingthesuitabilityofhemoplasma-infectedsheepforbiomedicalresearch。

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《Comparative Medicine》 |2014年第6期|共页
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Hampel Joseph A; Spath Samantha N; Bergin Ingrid L; Lim Ailam; Bolin Steven R; Dyson Melissa C;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Prevalence and Diagnosis of Hemotrophic Mycoplasma Infection in Research Sheep and Its Effects on Hematology Variables and Erythrocyte Membrane Fragility [J] . Hampel Joseph A., Spath Samantha N., Bergin Ingrid L., Comparative Medicine . 2014,第6期

机译：绵羊血养性支原体感染的流行，诊断及其对血液学变量和红细胞膜脆性的影响
2. Hemotrophic mycoplasma in Simmental cattle in Bavaria: prevalence, blood parameters, and transplacental transmission of ‘ Candidatus Mycoplasma haemobos’ and Mycoplasma wenyonii [J] . Florian Martin Niethammer, Julia Ade, Ludwig Eduard Hoelzle, Acta veterinaria scandinavica . 2018,第1期

机译：巴伐利亚西门塔尔牛的血型支原体：'念珠菌支原体和温支原体的患病率，血液参数和胎盘传播
3. Mycoplasma suis infection results endothelial cell damage and activation: new insight into the cell tropism and pathogenicity of hemotrophic mycoplasma [J] . Albina Sokoli, Katrin Groebel, Katharina Hoelzle, Veterinary research . 2013,第1期

机译：猪支原体感染导致内皮细胞损伤和活化：对嗜血性支原体的细胞嗜性和致病性的新见解
4. SUITABILITY OF IMMUNOHISTOCHEMISTRY FOR THE DIAGNOSIS OF MYCOPLASMA HYOPNEUMONIAE - INFECTIONS [C] . Lars Moorkamp, Elisabeth grosse Beilage, Marion Hewicker-Trautwein Congress ofthe International Pig Veterinary Society . 2008

机译：免疫组织化学的适用性诊断支原体渗透压 - 感染
5. Self-medicative behavior of sheep experiencing gastrointestinal nematode infections and the postingestive effects of tannins. [D] . Lisonbee, Larry D. 2008

机译：患有胃肠道线虫感染的绵羊的自我药物治疗行为和单宁的后继作用。
6. Prevalence and Diagnosis of Hemotrophic Mycoplasma Infection in Research Sheep and Its Effects on Hematology Variables and Erythrocyte Membrane Fragility [O] . Joseph A Hampel, Samantha N Spath, Ingrid L Bergin, 2014

机译：研究绵羊中嗜血支原体感染的流行诊断及其对血液学变量和红细胞膜脆性的影响
7. Mycoplasma suis infection results endothelial cell damage and activation: new insight into the cell tropism and pathogenicity of hemotrophic mycoplasma [O] . Albina Sokoli, Katrin Groebel, Katharina Hoelzle, 2013

机译：猪支原体感染导致内皮细胞损伤和活化：对嗜血性支原体的细胞嗜性和致病性的新见解
8. Laboratory Diagnosis of Mycoplasma Infections (Course 8226-C) [R] . Velleca, W. M. , Bird, B. R. , Forrester, F. T. 1980

机译：支原体感染的实验室诊断（课程8226-C）

Prevalence and Diagnosis of Hemotrophic Mycoplasma Infection in Research Sheep and Its Effects on Hematology Variables and Erythrocyte Membrane Fragility

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