• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Comparative Medicine >Housing Conditions Modulate the Severity of Mycoplasma pulmonis Infection in Mice Deficient in Class A Scavenger Receptor
【24h】

Housing Conditions Modulate the Severity of Mycoplasma pulmonis Infection in Mice Deficient in Class A Scavenger Receptor

机译：居住条件调节缺乏A类清道夫受体的小鼠中的肺炎支原体感染的严重程度。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mycoplasmosisisafrequentcausativemicrobialagentofcommunity-acquiredpneumoniaandhasbeenlinkedtoexacerbationofchronicobstructivepulmonarydisease.ThemacrophageclassAscavengerreceptor(SRA)facilitatestheclearanceofnoxiousparticles,oxidants,andinfectiousorganismsbyalveolarmacrophages.WeexaminedwildtypeandSRAsup#8211;/#8211;/supmice,housedineitherindividuallyventilatedorstaticfilter-topcagesthatwerecycledwithfreshbeddingevery14d,asamodelofgene#8211;environmentinteractionontheoutcomeofpulmonaryMycoplasmapulmonisinfection.IntracageNHsub3/subgasmeasurementswererecordeddailypriortoinfection.Micewereintranasallyinfectedwith1×10sup7/supcfuM.pulmonisUABCTandevaluatedat3,7,and14dafterinoculation.Wildtypemicecleared99.5%ofpulmonaryM.pulmonisby3dafterinfectionbutremainedchronicallyinfectedthroughthestudy.SRAsup#8211;/#8211;/supmicewerechronicallyinfectedwith40-foldhighermycoplasmanumbersthanwerewildtypemice.M.pulmoniscausedachronicmixedinflammatoryresponsethatwasaccompaniedwithhighlevelsofIL1#946;,KC,MCP1,andTNF#945;inSRAsup#8211;/#8211;/supmice,whereaspulmonaryinflammationinWTmicewasrepresentedbyamonocytosiswithelevationofIL1#946;.HousinghadaprominentinfluenceontheseverityandpersistenceofmycoplasmosisinSRAsup#8211;/#8211;/supmice.SRAsup-/-/supmicehousedinstaticcageshadanimprovedrecoveryandsignificantchangesinsurfactantproteinsSPAandSPDcomparedwithbaselinelevels.TheseresultsindicatethatSRAisrequiredtopreventchronicmycoplasmainfectionofthelung.Furthermore,environmentalconditionsmayexacerbatechronicinflammationinM.pulmonis-infectedSRAsup#8211;/#8211;/supmice.
机译：Mycoplasmosisisafrequentcausativemicrobialagentofcommunity-acquiredpneumoniaandhasbeenlinkedtoexacerbationofchronicobstructivepulmonarydisease.ThemacrophageclassAscavengerreceptor（SRA）facilitatestheclearanceofnoxiousparticles，氧化剂，andinfectiousorganismsbyalveolarmacrophages.WeexaminedwildtypeandSRA ＃8211; /＃8211; 小鼠，housedineitherindividuallyventilatedorstaticfilter-topcagesthatwerecycledwithfreshbeddingevery14d，asamodelofgene＃8211; environmentinteractionontheoutcomeofpulmonaryMycoplasmapulmonisinfection.IntracageNH <子> 3 gasmeasurementswererecordeddailypriortoinfection.Micewereintranasallyinfectedwith1×10 7 cfuM.pulmonisUABCTandevaluatedat3,7，and14dafterinoculation.Wildtypemicecleared99.5％ofpulmonaryM.pulmonisby3dafterinfectionbutremainedchronicallyinfectedthroughthestudy.SRA ＃8211; /＃8211; micewerechronicallyinfectedwith40-foldhighermycoplasmanumbersthanwerewildtypemice.M。肺炎引起的慢性混合性炎症反应帽子伴有高水平sofIL1＃946;，KC，MCP1和TNF＃945; inSRA ＃8211; /＃8211; 小鼠，其中WTMICew的肺炎是由单核细胞增多症引起的，IL1＃946升高;。对严重程度和持续性对 1＃的严重程度和持续性的哈达显性影响 1与基线水平相比，SRA -/-小鼠舍鼠笼shadan改善了回收率，并且表面活性蛋白SPA和SPD发生了显着变化。研究结果表明，SRA可能是该病反复发作的主要病因之一，可能是环境1。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号