首页> 外国专利> method for treating rhabdovirus infection in a mammalian subject suspected of having an infection, method for treating an autoimmune disease in a mammalian subject, method for treating inflammation in a mammalian subject, method for identifying a signaling modulator in cells via a receptor pathway 'tool-like' 4, method to select a compound to treat an infectious disease, method to select a compound to treat an autoimmune disease, method to select a compound to treat inflammation, transgenic non-human animal, cell or cell line, method for in vitro selection of a tool-like 4 or tram-trif receptor signaling activity modulator and method for in vivo selection of a tool-like 4 or tram-trif receptor signaling activity modulator

method for treating rhabdovirus infection in a mammalian subject suspected of having an infection, method for treating an autoimmune disease in a mammalian subject, method for treating inflammation in a mammalian subject, method for identifying a signaling modulator in cells via a receptor pathway 'tool-like' 4, method to select a compound to treat an infectious disease, method to select a compound to treat an autoimmune disease, method to select a compound to treat inflammation, transgenic non-human animal, cell or cell line, method for in vitro selection of a tool-like 4 or tram-trif receptor signaling activity modulator and method for in vivo selection of a tool-like 4 or tram-trif receptor signaling activity modulator

机译：在怀疑患有感染的哺乳动物受试者中治疗弹状病毒感染的方法，在哺乳动物受试者中治疗自身免疫疾病的方法，在哺乳动物受试者中治疗炎症的方法，通过受体途径在细胞中鉴定信号传导调节剂的方法如“ 4”，选择用于治疗传染病的化合物的方法，选择用于治疗自身免疫疾病的化合物的方法，选择用于治疗炎症的化合物的方法，转基因非人类动物，细胞或细胞系，体外方法类工具4或tram-trif受体信号传导活性调节剂的选择以及体内选择类工具4或tram-trif受体信号传导活性调节剂的方法

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摘要

METHOD TO TREAT RHABDOVIRUS INFECTION IN A MAMMAL SUBJECT SUSPECTED TO HAVE AN INFECTION "TOLL-LIKE" 4, METHOD TO SELECT A COMPOUND TO TREAT AN INFECTIOUS DISEASE, METHOD TO SELECT A COMPOUND TO TREAT AN AUTOIMMUNE DISEASE, METHOD TO SELECT A COMPOUND TO TREAT INFLAMMATION, HONEYLONE CULA NEOANOLE CELL FOR IN VITRO SELECTION OF A "TOLL-LIKE" 4 OR TRAM-TRIF RECEIVER SIGNALING ACTIVITY MODULATOR "Compositions and methods are provided for selecting and identifying compounds that modulate Toll-like receptor 4 (TLR4) signaling via CD14 and a ligand. Methods are provided for treating various disease states such as inflammation or autoimmune disease in mammalian subjects by modulating Toll-like receptor 4 (TLR4) pathway signaling via CD14 and a ligand. Transgenic nonhuman animals and methods for developing transgenic nonhuman animals are provided where transgenic nonhuman animals comprise a nonfunctional mutation for the CD14 gene.

机译：在怀疑患有传染性“ Toll样”的哺乳动物受试者中治疗弹状病毒感染的方法4，选择用于治疗感染性疾病的化合物的方法，选择用于治疗自身免疫性疾病的化合物的方法，选择用于治疗的化合物的方法用于体外选择“ Toll-like” 4或TRAM-TRIF接收信号活性调节剂的发炎，可乐新神经细胞“提供了组成和方法，用于选择和鉴定通过CD14调节Toll样受体4（TLR4）信号的化合物本发明提供了通过调节经由CD14和配体的Toll样受体4（TLR4）途径信号转导来治疗哺乳动物受试者的各种疾病状态，例如炎症或自身免疫疾病的方法，转基因非人类动物和开发转基因非人类动物的方法是在转基因非人类动物包含CD14基因的非功能性突变的情况下提供。

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公开/公告号BRPI0612419A2

专利类型
公开/公告日2010-11-09

原文格式PDF
申请/专利权人 THE SCRIPPS RESEARCH INSTITUTE;
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申请/专利号BR2006PI12419
发明设计人 BRUCE BEUTLER;ZHENGFAN JIANG;
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申请日2006-05-05
分类号A61K39/395;A61K39/205;G01N33/53;
国家 BR
入库时间 2022-08-21 18:47:21

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