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Increased Incidence of Vaginal Septum in C57BL/6J Mice Since 1976

机译：自1976年以来C57BL / 6J小鼠的阴道间隔发生率增加

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DecreasedfertilitywasobservedinabreedingcolonyofC57BL/6Jmice.Onexamination,adorsoventralvaginalseptumwasdetectedinmanyfemales.Thisdefectwasidentifiedin1976,withincidenceof4.0%inthisstrain.Ourobjectivewastodeterminewhetherincidenceofthisconditionhasincreasedandwhetherthisdefectwasassociatedwiththeobservedinfertility.Wereportincidenceof11.3%,nearlytripletheoriginalreportedincidence.Forcomparison,incidenceofvaginalseptuminC57BL/6Nfemaleswasdeterminedandwasfoundtobe1%.WeperformedabreedingstudyusingnormalandaffectedC57BL/6Jfemalestoevaluatefertilityinaffectedfemales.Ourdatawereconsistentwiththoseofthe1976report;fertilitywasdecreasedinfemaleswithanintactvaginalseptum.In50%ofaffectedfemales,theseptumremainedintactafterbreeding.Thefertilityforthissubgroupofvaginalseptum-retainedfemaleswas14.3%,comparedwith85.7%infemaleswhoseseptumrupturedand75.0%innormalfemales(statisticallysignificant,P=0.02).Onthebasisofourresults,weprovideanimalandfinanciallossdataduetothedefect.Lastly,weprovidesuggestionsonhowtominimizeanimallossesandbeinaccordancewiththeprinciplesofthe3Rs(replacement,refinement,reduction).
机译：DecreasedfertilitywasobservedinabreedingcolonyofC57BL / 6Jmice.Onexamination，adorsoventralvaginalseptumwasdetectedinmanyfemales.Thisdefectwasidentifiedin1976，withincidenceof4.0％inthisstrain.Ourobjectivewastodeterminewhetherincidenceofthisconditionhasincreasedandwhetherthisdefectwasassociatedwiththeobservedinfertility.Wereportincidenceof11.3％，nearlytripletheoriginalreportedincidence.Forcomparison，incidenceofvaginalseptuminC57BL / 6Nfemaleswasdeterminedandwasfoundtobe1％.Weperformedab​​reedingstudyusingnormalandaffectedC57BL / 6Jfemalestoevaluatefertilityinaffectedfemales.Ourdatawereconsistentwiththoseofthe1976report; fertilitywasdecreasedinfemaleswithanintactvaginalseptum.In50％ofaffectedfemales，theseptumremainedintactafterbreeding.Thefertilityforthissubgroupofvaginalseptum retainedfemaleswas14。 3％，而破裂的女性为85.7％，正常女性为75.0％（统计学上显着，P = 0.02）。基于上述结果，由于缺陷而提供了动物土地财务损失数据。如何根据3Rs的原理（更换，细化，减少）最小化动物损失。

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