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Immune Response of Chimpanzees Infected with Human Mycoplasmas

机译:感染人类支原体的黑猩猩的免疫反应

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Sevenchimpanzeeswereinoculatedintra-articularlywithoneofthreeMycoplasmaspecies.Threechimpanzeeswereinoculatedwithclinicalsynovialisolate1620,andonewasinoculatedwithtypestrainPG-21ofM.hominis.Thefifthanimalwasinoculatedwithclinicalsynovialisolate2010B,andthesixthwasinoculatedwiththetypestrainCOofUreaplasmaurealyticum.TheseventhanimalwasinoculatedwithclinicalisolatePI-1428ofM.pneumoniae.Thesynovialisolatesinducedintenseantibodyresponses,antibodiesrecognizedmoreantigens,andthereactiveantigensweredistinctfromthecorrespondingtypestrains.Chimpanzeesinfectedwithsynovialisolate1620,butnottypestrainPG-21,recognizedantigensofmolecularmass223,208,168,165,155,150,142,134,115,105,52,50,45,38,and36kDa.Thechimpanzeeinfectedwithsynovialisolate2010B,butnottypestrainCO,recognizedantigensatabout277,237,62,57,and43kDa.ThemajorantibodyreactiveantigensofM.pneumoniaeisolatePI-1428migratedatabout170,90,56,40,32,and30kDa.ThereportedbiologicactivitiesofantigenicproteinsderivedfromtheseMycoplasmaspeciesarereviewed.
机译:Sevenchimpanzeeswereinoculatedintra-articularlywithoneofthreeMycoplasmaspecies.Threechimpanzeeswereinoculatedwithclinicalsynovialisolate1620,andonewasinoculatedwithtypestrainPG-21ofM.hominis.Thefifthanimalwasinoculatedwithclinicalsynovialisolate2010B,andthesixthwasinoculatedwiththetypestrainCOofUreaplasmaurealyticum.TheseventhanimalwasinoculatedwithclinicalisolatePI-1428ofM.pneumoniae.Thesynovialisolatesinducedintenseantibodyresponses,antibodiesrecognizedmoreantigens,andthereactiveantigensweredistinctfromthecorrespondingtypestrains.Chimpanzeesinfectedwithsynovialisolate1620,butnottypestrainPG-21,recognizedantigensofmolecularmass223,208,168,165,155,150,142,134,115,105,52,50,45,38,and36kDa.Thechimpanzeeinfectedwithsynovialisolate2010B,但未鉴定出菌株CO,公认的抗原约为277,237,62,57和43kDa。肺炎支原体分离物PI-1428的主要抗体反应性抗原约在170、90、56、40、32和30kDa处迁移。从这些支原体物种衍生的报道的抗原蛋白生物学活性ed。

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