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Immune response of chimpanzees infected with human mycoplasmas

机译：感染人类支原体的黑猩猩的免疫反应

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摘要

Seven chimpanzees were inoculated intra-articularly with one of three Mycoplasma species. Three chimpanzees were inoculated with clinical synovial isolate 1620, and one was inoculated with type strain PG-21 of M. hominis. The fifth animal was inoculated with clinical synovial isolate 2010B, and the sixth was inoculated with the type strain CO of Ureaplasma urealyticum. The seventh animal was inoculated with clinical isolate PI-1428 of M. pneumoniae. The synovial isolates induced intense antibody responses, antibodies recognized more antigens, and the reactive antigens were distinct from the corresponding type strains. Chimpanzees infected with synovial isolate 1620, but not type strain PG-21, recognized antigens of molecular mass 223, 208, 168, 165, 155, 150, 142, 134, 115, 105, 52, 50, 45, 38, and 36 kDa. The chimpanzee infected with synovial isolate 2010B, but not type strain CO, recognized antigens at about 277, 237, 62, 57, and 43 kDa. The major antibody reactive antigens of M. pneumoniae isolate PI-1428 migrated at about 170, 90, 56, 40, 32, and 30 kDa. The reported biologic activities of antigenic proteins derived from these Mycoplasma species are reviewed.
机译：七个黑猩猩关节内接种了三种支原体物种之一。将三只黑猩猩接种临床滑膜分离株1620，将一只黑猩猩接种人型分枝杆菌PG-21型。第五只动物接种临床滑膜分离株2010B，第六只动物接种解脲脲原体CO型菌株。用肺炎支原体的临床分离株PI-1428接种第七只动物。滑膜分离株诱导强烈的抗体应答，抗体识别更多的抗原，并且反应性抗原与相应的类型菌株不同。感染了滑膜分离株1620而不是类型菌株PG-21的黑猩猩识别了分子量分别为223、208、168、165、155、150、142、134、115、105、52、50、45、38和36的抗原kDa。被滑膜分离株2010B感染但未感染CO型的黑猩猩在大约277、237、62、57和43 kDa处识别抗原。肺炎支原体分离株PI-1428的主要抗体反应性抗原以约170、90、56、40、32和30kDa迁移。评论了这些支原体物种的抗原蛋白的生物学活性。

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