Sheep Model for Study of Maternal Adrenal Gland Function During Pregnancy

Keller-Wood Maureen; Cudd Timothy A.; nbsp; Norman Wendy; Caldwell Sara M.; Wood Charles E.

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Sheep Model for Study of Maternal Adrenal Gland Function During Pregnancy

机译：羊模型用于孕妇孕期肾上腺功能的研究

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Ourgoalwastodevelopamodelforthestudyofmaternaladrenalglandregulationandtheeffectsofmaternalcortisolsecretiononfetalhomeostasis.Atabout108daysofgestation,beforethetimeofrapidfetalgrowthorfetaladrenocorticalmaturation,ewes,underhalothaneanesthesiawithcontrolledventilationandpositionedinsternalrecumbency,wereadrenalectomized.Ewesweretreatedwithaldosteronebyintravenousinfusion(3g/kgofbodyweightperday)toinducenormallate-gestationaldosteroneconcentration.Eweswerealsotreatedwithcortisol;for2postoperativedays,thisinfusion(1to2g/kgpermin)inducedplasmaconcentrationsimilartothatassociatedwithstress.Thereafter,thedosageofcortisolwasreducedtoinduceplasmavaluessimilartonormallate-gestationcortisolconcentrationinewes(1mg/kgperday),ortovaluesinnonpregnantewes(0.6mg/kgperday).Administrationofcortisolandaldosteronewasrequiredtopreventelectrolyteimbalanceandsignsofhypoadrenocorticism.Withsteroidreplacement,plasmaprotein,electrolyte,andglucoseconcentrationsinadrenalectomizedeweswerenotdifferentfromthoseinsham-operatedpregnantewes.Of11adrenalectomizedewes,onediedasaresultoffailureoftheinfusionpump,andonediedasaresultofinappropriatetreatmentforhypoglycemia.Oftheremainingewes,twoabortedfetuses,threeeweseachdeliveredoneliveandonedeadfetus,twodeliveredlivesingletonfetuses,andtwodeliveredtwins.Therefore,thismodelofrelativehypoadrenocorticisminpregnancyisfeasibleandpracticalforstudyingtheinfluenceofmaternalcortisolconcentrationonmaternalandfetalhomeostasis.

机译：Ourgoalwastodevelopamodelforthestudyofmaternaladrenalglandregulationandtheeffectsofmaternalcortisolsecretiononfetalhomeostasis.Atabout108daysofgestation，beforethetimeofrapidfetalgrowthorfetaladrenocorticalmaturation，母羊，underhalothaneanesthesiawithcontrolledventilationandpositionedinsternalrecumbency，wereadrenalectomized.Ewesweretreatedwithaldosteronebyintravenousinfusion（3G / kgofbodyweightperday）toinducenormallate-gestationaldosteroneconcentration.Eweswerealsotreatedwithcortisol; for2postoperativedays，thisinfusion（1to2g / kgpermin）inducedplasmaconcentrationsimilartothatassociatedwithstress.Thereafter，thedosageofcortisolwasreducedtoinduceplasmavaluessimilartonormallate-gestationcortisolconcentrationinewes（1毫克/ kgperday），ortovaluesinnonpregnantewes（为0.6mg /肾上腺皮质激素，血浆蛋白，电解质和葡萄糖的浓度与肾上腺素电化的丝毫没有区别假operatedpregnantewes.Of11adrenalectomizedewes，onediedasaresultoffailureoftheinfusionpump，andonediedasaresultofinappropriatetreatmentforhypoglycemia.Oftheremainingewes，twoabortedfetuses，threeeweseachdeliveredoneliveandonedeadfetus，twodeliveredlivesingletonfetuses，andtwodeliveredtwins.Therefore，thismodelofrelativehypoadrenocorticisminpregnancyisfeasibleandpracticalforstudyingtheinfluenceofmaternalcortisolconcentrationonmaternalandfetalhomeostasis。

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《Comparative Medicine》 |1998年第5期|共页
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Keller-Wood Maureen; Cudd Timothy A.; nbsp; Norman Wendy; Caldwell Sara M.; Wood Charles E.;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Sheep model for study of maternal adrenal gland function during pregnancy [J] . Maureen Keller-Wood, Timothy A. Cudd, Wendy Norman Laboratory Animal Science . 1998,第5期

机译：羊模型用于孕妇孕期肾上腺功能的研究
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Sheep Model for Study of Maternal Adrenal Gland Function During Pregnancy

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