Hereditary and Histologic Characteristics of the CF1/b cac Mouse Cataract Model

Kondo Tomohiro; Nagai Hiroaki; Kawashima Takamune; Taniguchi Yusuke; Koyabu Nozomu; Takeshita Ai; Kusakabe Ken-Takeshi; Okada Toshiya

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Hereditary and Histologic Characteristics of the CF1/b cac Mouse Cataract Model

机译：CF1 / b cac小鼠白内障模型的遗传和组织学特征

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AsubstrainofmiceoriginatingfromtheCF1strain(anoutbredcolony)rearedatOsakaPrefectureUniversity(CF1/bcacmice)developscataractsbeginningat14dold.Affectedmicewerefullyviableandfertileandhaddevelopedcataractsby22dofage.Theincidenceofcataractsdidnotdifferbetweenmaleandfemalemice.Histologically,14-wk-oldCF1/bcacmiceshowedvacuolatedlensepithelialcells,swollenlensfibers,manypyknoticnuclei,andvacuolationofthelenscortex.Toelucidatethemodeofinheritance,weanalyzedheterozygousmutantshybridsgeneratedfromCF1/bcacandwildtypeBALB/cmiceandtheoffspringofthebackcrossedheterozygousmutants.Noneoftheheterozygousmutantswasaffected,buttheratioofaffectedtounaffectedmicewas1:3amongtheoffspringoftheheterozygousmutants.Theinitialgenomewidescreenof20affectedbackcrossedoffspring(CF1/bcac×[CF1/bcac×BALB/c])indicatedthatthemutantgeneresidesonchromosome16.Forfurthermapping,weusedaffectedprogenyofCF1/bcac×(CF1/bcac×MSM/Ms)mice.WeconcludedthatthecataractsinCF1/bcacmiceareinheritedthroughanautosomalrecessivemutationandthatthemutantgeneislocatedonmousechromosome16betweenD16Mit5andD16Mit92andbetweenD16Mit92andD16Mit201.ThemappingofthemutantgeneoftheCF1/bcacmicetomousechromosome16providesthepositionalinformationnecessarytoidentifythecandidategeneresponsiblefortheCF1/bcacphenotype.

机译：AsubstrainofmiceoriginatingfromtheCF1strain（anoutbredcolony）rearedatOsakaPrefectureUniversity（CF1 / bcacmice）developscataractsbeginningat14dold.Affectedmicewerefullyviableandfertileandhaddevelopedcataractsby22dofage.Theincidenceofcataractsdidnotdifferbetweenmaleandfemalemice.Histologically，14-WK-oldCF1 / bcacmiceshowedvacuolatedlensepithelialcells，swollenlensfibers，manypyknoticnuclei，andvacuolationofthelenscortex.Toelucidatethemodeofinheritance，weanalyzedheterozygousmutantshybridsgeneratedfromCF1 / bcacandwildtypeBALB / cmiceandtheoffspringofthebackcrossedheterozygousmutants.Noneoftheheterozygousmutantswasaffected，buttheratioofaffectedtounaffectedmicewas1：3 amongtheoffspringoftheheterozygousmutants.Theinitialgenomewidescreenof20affectedbackcrossedoffspring（CF1 / bcac×[CF1 / bcac×BALB / c]）表示该突变基因位于染色体16上。为了进一步作图，我们将CF1 / bcac×（CF1 / bcac×MSM / MS）的子代用于受影响的小鼠。突变基因位于D16Mit5和D16Mit92之间，D16Mit92和D16Mit201之间的小鼠染色体16上。

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《Comparative Medicine》 |2014年第5期|共页
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Kondo Tomohiro; Nagai Hiroaki; Kawashima Takamune; Taniguchi Yusuke; Koyabu Nozomu; Takeshita Ai; Kusakabe Ken-Takeshi; Okada Toshiya;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Hereditary and Histologic Characteristics of the CF1/b cac Mouse Cataract Model [J] . Kondo Tomohiro, Nagai Hiroaki, Kawashima Takamune, Comparative Medicine . 2014,第5期

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2. Novel cataract mouse model using ddY strain: hereditary and histological characteristics. [J] . Kondo T, Nagai H, Morioka H, The Journal of Veterinary Medical Science . 2010,第2期

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3. Novel Cataract Mouse Model Using ddY Strain: Hereditary and Histological Characteristics [J] . Hiroaki NAGAI, Hiroshi MORIOKA, Ken Takeshi KUSAKABE, The Journal of Veterinary Medical Science . 2010,第2期

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7. Rupture of Lens Cataract: A Novel Hereditary Recessive Cataract Model in the Mouse [O] . FUMITO IIDA, YOSHIBUMI MATSUSHIMA, HIROSHI HIAI, 1997

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Hereditary and Histologic Characteristics of the CF1/b cac Mouse Cataract Model

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