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首页> 外文期刊>Biology Open >The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms
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The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms

机译：snRNA处理复合物Integrator是通过独特的机制进行纤毛生成和动力蛋白募集到核膜所必需的

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摘要

We previously reported that the small nuclear RNA processing complex, Integrator, is required for dynein recruitment to the nuclear envelope at mitotic onset in cultured human cells. We now report an additional role for INT in ciliogenesis. Depletion of INT subunits from cultured human cells results in loss of primary cilia. We provide evidence that the requirements for INT in dynein localization and ciliogenesis are uncoupled: proteins essential for ciliogenesis are not essential for dynein recruitment to the nuclear envelope, while depletion of known regulators of perinuclear dynein has minimal effects on ciliogenesis. Taken together, our data support a model in which INT ensures proper processing of distinct pools of transcripts encoding components that independently promote perinuclear dynein enrichment and ciliogenesis.
机译：我们先前曾报道过，在培养的人类细胞中，有丝分裂发生时，动力蛋白需要募集到小核RNA加工复合体Integrator。现在，我们报告INT在纤毛发生中的其他作用。培养的人类细胞中INT亚基的耗竭导致原发纤毛的丧失。我们提供的证据表明，在动力蛋白定位和纤毛生成中对INT的要求是不耦合的：纤毛生成所必需的蛋白质对于将动力蛋白募集到核膜上不是必需的，而消除已知的周围核动力蛋白调节剂对纤毛生成的影响却很小。综上所述，我们的数据支持一个模型，在该模型中，INT确保正确处理不同的转录物成分库，这些转录物成分独立地促进核周动力蛋白的富集和纤毛生成。

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