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首页> 外文期刊>Comparative and functional genomics >The Heat Shock Response ofMycobacterium tuberculosis: Linking Gene Expression, Immunology and Pathogenesis
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The Heat Shock Response ofMycobacterium tuberculosis: Linking Gene Expression, Immunology and Pathogenesis

机译：结核分枝杆菌的热休克反应：基因表达，免疫学和发病机制的联系。

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The regulation of heat shock protein (HSP) expression is critically important to pathogens such asMycobacterium tuberculosisand dysregulation of the heat shock response results in increased immune recognition of the bacterium and reducedsurvival during chronic infection. In this study we use a whole genome spottedmicroarray to characterize the heat shock response ofM. tuberculosis. We also begin a dissection of this important stress response by generating deletion mutants that lackspecific transcriptional regulators and examining their transcriptional profiles underdifferent stresses. Understanding the stimuli and mechanisms that govern heat shockin mycobacteria will allow us to relate observedin vivoexpression patterns of HSPsto particular stresses and physiological conditions. The mechanisms controlling HSPexpression also make attractive drug targets as part of a strategy designed to enhanceimmune recognition of the bacterium.
机译：热休克蛋白（HSP）表达的调节对于诸如结核分枝杆菌的病原体至关重要，而热休克应答的失调会导致细菌的免疫识别增加，并降低慢性感染期间的存活率。在这项研究中，我们使用全基因组斑点微阵列来表征M的热激反应。结核。我们还通过产生缺乏特异性转录调节因子的缺失突变体并在不同压力下检查其转录谱，开始剖析这种重要的应激反应。了解控制分枝杆菌热休克的刺激和机制将使我们能够将观察到的HSP体内表达模式与特定压力和生理状况联系起来。控制HSP表达的机制也将吸引人的药物靶标作为旨在增强对细菌的免疫识别的策略的一部分。

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