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Effect of Diazoxide on Heat Shock Protein Expression and Physiological Response to Hemorrhagic Shock and Cerebral Stroke; Final Report, April 1, 2004 to June 30, 2006

机译：二氮嗪对热休克蛋白表达及对失血性休克和脑卒中的生理反应的影响;最终报告，2004年4月1日至2006年6月30日

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Our team tested the hypothesis that pharmacological induction of ischemic preconditioning (IPC) can offer cytoprotection and preserve vital tissues after cerebral stroke with hemorrhagic shock. The compound, diazoxide (DZ), mimics IPC through its effects as a mitochondrial KATP channel opener and succinate dehydrogenase inhibitor. We examined the effect of DZ under two IPC protocols: delayed preconditioning and postconditioning in an anesthetized rat model of hemorrhagic shock, and combined in some experimental groups with cerebral vascular occlusion (stroke). When DZ was administered 24 hours prior to shock (delayed preconditioning), it significantly reduced hyperglycemia, which in vehicle-treated animals persisted after resuscitation.

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作者
O'Sullivan, J.;
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年度 2006
页码 p.1-38
总页数 38
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Ischemia; Cerebral stroke; Hemorrhagic shock; Physiological response; Survival rate; Mitochondria; Ischemia; Lactate; Glucose;

机译：缺血;脑卒中;失血性休克;生理反应;存活率;线粒体;缺血;乳酸;葡萄糖;

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1. Diazoxide, as a postconditioning and delayed preconditioning trigger, increases HSP25 and HSP70 in the central nervous system following combined cerebral stroke and hemorrhagic shock. [J] . OSullivan JC, Yao XL, Alam H, Journal of neurotrauma . 2007,第3期

机译：在合并中风和失血性休克后，二氮嗪作为一种后调节和延迟的预处理触发，会增加中枢神经系统中的HSP25和HSP70。
2. Expression of Heat Shock and Other Stress Response Proteins in Ticks and Cultured Tick Cells in Response toAnaplasmaspp. Infection and Heat Shock [J] . MargaritaVillar, NievesAyllón, Ann T.Busby, International journal of proteomics . 2010,第1期

机译：热激和其他应激反应蛋白在Ti和培养的ick细胞中对拟南芥的反应中的表达。感染和热休克
3. Heat shock proteins gene expression and physiological responses in durum wheat (Triticum durum) under salt stress [J] . Al Khateeb Wesam, Muhaidat Riyadh, Alahmed Sanaa, Physiology and Molecular Biology of Plants . 2020,第8期

机译：盐胁迫下硬粒小麦（Triticum）中的热休克蛋白基因表达及生理反应
4. Heat Shock Exposure Influences Tissue Variations in 70 kDa Heat Stress Proteins Expression of Common Carp [C] . Shangyuan Li, rnYabin Ye, rnXiaoping Zheng, Progress in Environmental Science and Technology . 2007

机译：热休克暴露影响鲤鱼70 kDa热应激蛋白表达的组织变异
5. The expression of heat shock protein 70, heat shock protein 90 and heat shock factor 1 within the bovine midcycle corpus luteum after stimulation with temperature in vitro and PGF2alpha in vitro and in vivo. [D] . Kopka, Melissa N. 2006

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6. Expression of Heat Shock and Other Stress Response Proteins in Ticks and Cultured Tick Cells in Response to Anaplasma spp. Infection and Heat Shock [O] . Margarita Villar, Nieves Ayllón, Ann T. Busby, 2010

机译：热激和其他应激反应蛋白的表达在Ti和培养的ick细胞中对无性生殖的反应。感染和热休克
7. Characterization of the Heat Shock Response in Cultured Sugarcane Cells 1: I. Physiology of the Heat Shock Response and Heat Shock Protein Synthesis [O] . Moisyadi, Stefan, Harrington, H. Michael 1989

机译：培养的甘蔗细胞中热休克反应的特征1：I.热休克反应的生理和热休克蛋白合成

Effect of Diazoxide on Heat Shock Protein Expression and Physiological Response to Hemorrhagic Shock and Cerebral Stroke; Final Report, April 1, 2004 to June 30, 2006

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