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首页> 外文期刊>Comparative Medicine >Mouse Mammary Gland Is Refractory to the Effects of Ethanol after Natural Lactation
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Mouse Mammary Gland Is Refractory to the Effects of Ethanol after Natural Lactation

机译：小鼠乳腺对自然泌乳后乙醇的作用不敏感

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Ethanolisadietaryfactorthatdose-dependentlyincreasesbreastcancerriskinwomen.WepreviouslyhaveshownthatethanolincreasesmammaryepithelialdensitythroughincreasedbranchingafterdietaryexposureduringpubertyinCD2/F1mice.Toextendthesestudiestoparousmiceinabreastcancermodel,weusedatransgenicmousemodelofhumanparity-associatedbreastcancer,theFVB-MMTV-Her2/Neumouse,whichoverexpresseswildtypeEGFR2,resultinginconstitutiveactivationofgrowthsignalinginthemammaryepithelium.Herewedescribetheshort-termeffectsofethanolfeedingonprogressionthroughinvolution.Micewerefeddietssupplementedwith0%,0.5%,1%,or2%ethanolfor4,9,or14dstartingonday21oflactation(thatis,atthestartofnaturalpostlactationalinvolution).Unlikeperipubertalmiceexposedtoethanol,postlactationaldamsshowednochangesinbodyweight;liver,spleen,andkidneyweights;andpathology.Ethanolexposurehadnoeffectonmammaryglandlobulardensityandadipocytesizethroughoutinvolution.Likewise,theinfiltrationofinflammatorycellsandserumoxidizedlipidspecieswereunchangedbydiet,suggestingthatethanolfeedinghadnoeffectonlocalinflammation(leukocyteinfiltration)orsystemicinflammation(oxidizedlipids).Inconclusion,ethanolexposureofparousdamshadnoeffectonmammaryglandstructureortheregressionofthelactatingmammaryglandtoarestingstate.Theperiodofinvolutionthatfollowsnaturallactationappearstoberefractorytodevelopmentaleffectsofethanolonmammaryepithelium.
机译：Ethanolisadietaryfactorthatdose-dependentlyincreasesbreastcancerriskinwomen.WepreviouslyhaveshownthatethanolincreasesmammaryepithelialdensitythroughincreasedbranchingafterdietaryexposureduringpubertyinCD2 / F1mice.Toextendthesestudiestoparousmiceinabreastcancermodel，weusedatransgenicmousemodelofhumanparity-associatedbreastcancer，theFVB-MMTV-HER2 / Neumouse，whichoverexpresseswildtypeEGFR2，resultinginconstitutiveactivationofgrowthsignalinginthemammaryepithelium.Herewedescribetheshort-termeffectsofethanolfeedingonprogressionthroughinvolution.Micewerefeddietssupplementedwith0％，0.5％，1％，OR2％ethanolfor4,9，or14dstartingonday21oflactation（thatis，atthestartofnaturalpostlactationalinvolution与暴露于乙醇的青春期小鼠不同，泌乳期后的水肿表明体重无变化;肝脏，脾脏和肾脏的重量没有改变;病理学。乙醇暴露对乳腺的小叶密度没有影响，同样，炎症物质浸润后被脂质氧化，脂质改变总结认为，乙醇对食性哺乳动物的乳腺腺体结构的影响不存在。

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