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首页> 外文期刊>Biology Open >Contribution of non-circadian neurons to the temporal organization of locomotor activity
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Contribution of non-circadian neurons to the temporal organization of locomotor activity

机译：非昼夜神经元对运动活动的时间组织的贡献

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In the fruit fly,Drosophila melanogaster, the daily cycle of rest and activity is a rhythmic behavior that relies on the activity of a small number of neurons. The small ventral lateral neurons (sLNvs) are considered key in the control of locomotor rhythmicity. Previous work from our laboratory has showed that these neurons undergo structural remodeling on their axonal projections on a daily basis. Such remodeling endows sLNvs with the possibility to make synaptic contacts with different partners at different times throughout the day, as has been previously described. By using different genetic tools to alter membrane excitability of the sLNv putative postsynaptic partners, we tested their functional role in the control of locomotor activity. We also used optical imaging to test the functionality of these contacts. We found that these different neuronal groups affect the consolidation of rhythmic activity, suggesting that non-circadian cells are part of the circuit that controls locomotor activity. Our results suggest that new neuronal groups, in addition to the well-characterized clock neurons, contribute to the operations of the circadian network that controls locomotor activity inD. melanogaster.
机译：在果蝇中，果蝇的休息和活动的每日周期是一种节律性行为，它依赖于少数神经元的活动。小腹外侧神经元（sLNvs）被认为是控制运动节律的关键。我们实验室的先前工作表明，这些神经元每天都在其轴突投影上进行结构重塑。如前所述，这种重塑赋予sLNvs在一天中的不同时间与不同伴侣进行突触接触的可能性。通过使用不同的遗传工具来改变sLNv假定的突触后伙伴的膜兴奋性，我们测试了它们在运动活动控制中的功能。我们还使用光学成像来测试这些触点的功能。我们发现这些不同的神经元组影响节律活动的巩固，表明非昼夜节律细胞是控制运动活动的电路的一部分。我们的研究结果表明，新的神经元群，除了特征明确的时钟神经元外，还有助于控制D中自发活动的昼夜节律网络的运作。忧郁症。

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