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首页> 外文期刊>Biology Open >Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats
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Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats

机译：慢性抑制睾丸激素代谢对淋巴结切除大鼠缺血/再灌注致心肌损伤后心脏重构的影响

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摘要

The effects of testosterone on cardiovascular homeostasis are still not well understood. The objective of this work was to evaluate the effects of testosterone in the absence or presence of inhibition of Aromatase (4-hydroxyandrostenedione) and/or 5α reductase (Finasteride) enzymatic activities on the myocardial remodeling 30?days after ischemia/reperfusion (I/R) injury in gonadectomized rats. Results showed that testosterone administration to ORX rats resulted in decreased myocardial damaged area, inflammatory infiltrates and reduced MMP-3 and 13 expressions. Interestingly, Finasteride administration resulted in a greater decrease in scar tissue, inflammatory infiltrates, along with a significant decrease in MMP-3 and 13 expressions. In contrast, 4-hydroxyandrostenedione administrations increased all parameters. Our results suggest that testosterone does not have a direct effect since simultaneous inhibition of aromatase and 5α-reductase did not induce significant changes in I/R induced myocardial injury.
机译：睾丸激素对心血管稳态的影响仍未得到很好的了解。这项工作的目的是评估在不存在或不存在芳香化酶（4-羟基雄烯二酮）和/或5α还原酶（非那雄胺）酶促活性抑制的情况下，睾丸激素对缺血/再灌注后30天心肌重构的影响（I / R）淋巴切除大鼠的损伤。结果表明，向ORX大鼠施用睾丸激素可减少心肌损伤面积，炎症浸润并降低MMP-3和13的表达。有趣的是，非那雄胺的施用导致疤痕组织，炎性浸润的减少更大，同时MMP-3和13的表达也明显减少。相反，4-羟基雄烯二酮给药增加了所有参数。我们的结果表明，睾丸激素没有直接作用，因为同时抑制芳香化酶和5α-还原酶不会在I / R诱导的心肌损伤中引起显着变化。

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