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The Progress of Methylation Regulation in Gene Expression of Cervical Cancer

机译：甲基化调控在宫颈癌基因表达中的研究进展

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Cervical cancer is one of the most common gynecological tumors in females, which is closely related to high-rate HPV infection. Methylation alteration is a type of epigenetic decoration that regulates the expression of genes without changing the DNA sequence, and it is essential for the progression of cervical cancer in pathogenesis while reflecting the prognosis and therapeutic sensitivity in clinical practice. Hydroxymethylation has been discovered in recent years, thus making 5-hmC, the more stable marker, attract more attention in the field of methylation research. As markers of methylation, 5-hmC and 5-mC together with 5-foC and 5-caC draw the outline of the reversible cycle, and 6-mA takes part in the methylation of RNA, especially mRNA. Furthermore, methylation modification participates in ncRNA regulation and histone decoration. In this review, we focus on recent advances in the understanding of methylation regulation in the process of cervical cancer, as well as HPV and CIN, to identify the significant impact on the prospect of overcoming cervical cancer.
机译：宫颈癌是女性中最常见的妇科肿瘤之一，它与高比例的HPV感染密切相关。甲基化改变是一种表观遗传修饰，可调节基因表达而无需改变DNA序列，对于宫颈癌的发病机制发展至关重要，同时也反映了临床实践中的预后和治疗敏感性。近年来发现了羟甲基化，因此使5-hmC（更稳定的标记）在甲基化研究领域引起了更多关注。作为甲基化标记，5-hmC和5-mC以及5-foC和5-caC画出了可逆循环的轮廓，而6-mA参与了RNA的甲基化，尤其是mRNA。此外，甲基化修饰参与ncRNA调控和组蛋白修饰。在这篇综述中，我们重点关注子宫颈癌，HPV和CIN在甲基化调控过程中的最新进展，以确定对克服子宫颈癌前景的重大影响。

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