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ICBP90 Regulation of DNA Methylation, Histone Ubiquitination, and Tumor Suppressor Gene Expression in Breast Cancer Cells.

机译：ICBp90调节乳腺癌细胞中的DNa甲基化，组蛋白泛素化和肿瘤抑制基因表达。

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In mammals and other higher eukaryotes, SRA-RING proteins are essential for global maintenance of DNA methylation. This research project focuses on the discovery of new ubiquitination targets for the Arabidopsis SRA- RING protein VIM1 and the human SRA-RING protein UHRF1. Additionally, it will closely examine the methylcytosine-binding specificity of UHRF1, with a specific focus on non-CpG contexts. The proposed work is ongoing, and so far the major accomplishments include creation of relevant plant lines, development of in vitro assays, and profiling of mRNA expression in null mutants.

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Shook, M. S.; Cravens, E. N.; Hughes, E. J.; Coonrod, S. A.; Richards, E. J.;
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年度 2013
页码 1-11
总页数 11
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Breast cancer; Neoplasms; Assaying; Chromatin; Global; Histones; In vitro analysis; Mammals; Methylation; Proteins; Targets; Tumor suppressors; Ubiquitination; Epigenetics;

机译：乳腺癌;肿瘤;测定;染色质;全球;组蛋白;体外分析;哺乳动物;甲基化;蛋白质;靶标;肿瘤抑制因子;泛素化;表观遗传学;

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专利

1. Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells. [J] . Qi Xie, Qian Bai, Ling-Yun Zou, Genes, Chromosomes and Cancer . 2014,第5期

机译：金雀异黄素抑制人乳腺癌细胞中的DNA甲基化并增加肿瘤抑制基因的表达。
2. (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. [J] . Nandakumar V, Vaid M, Katiyar SK Carcinogenesis . 2011,第4期

机译：（-）-Epigallocatechin-3-gallate通过减少人类皮肤癌细胞中的DNA甲基化并增加组蛋白乙酰化，重新激活沉默的抑癌基因Cip1 / p21和p16INK4a。
3. Role of histone modifications and DNA methylation in the regulation of O6-methylguanine-DNA methyltransferase gene expression in human stomach cancer cells. [J] . Meng CF, Zhu XJ, Peng G, Cancer investigation . 2010,第4期

机译：组蛋白修饰和DNA甲基化在人胃癌细胞中调节O6-甲基鸟嘌呤-DNA甲基转移酶基因表达的作用。
4. Applying formal concept analysis for visualizing DNA methylation status in breast cancer tumor subtypes [C] . Amin Islam Ibrahim, Kassim Samar K., Hassanien Aboul Ella, International Computer Engineering Conference . 2014

机译：应用形式概念分析来可视化乳腺癌肿瘤亚型的DNA甲基化状态
5. Aberrant epigenetic silencing of tumor suppressor genes in human cancer: The roles of DNA hypermethylation and the histone code. [D] . Fahrner, Jill A. 2005

机译：人类癌症中肿瘤抑制基因的异常表观遗传沉默：DNA高度甲基化和组蛋白密码的作用。
6. (−)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes Cip1/p21 and p16INK4a by reducing DNA methylation and increasing histones acetylation in human skin cancer cells [O] . Vijayalakshmi Nandakumar, Mudit Vaid, Santosh K. Katiyar -1

机译：（-）-Epigallocatechin-3-gallate通过减少人类皮肤癌细胞中的DNA甲基化并增加组蛋白乙酰化来重新激活沉默的抑癌基因Cip1 / p21和p16INK4a
7. Suppressor of cytokine signaling (SOCS) genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells. [O] . Moon-Hong Kim, Moon-Sun Kim, Wonwoo Kim, 2015

机译：细胞因子信号传导（sOCs）基因的抑制因子被DNa高甲基化和组蛋白去乙酰化以及对宫颈癌细胞放射治疗的调节反应所沉默。
8. ICBP90 Regulation of DNA Methylation, Histone Ubiquitination, and Tumor Suppressor Gene Expression in Breast Cancer Cells. [R] . Shook, M. S., Cravens, E. N., Hughes, E. J., 2012

机译：ICBp90调节乳腺癌细胞中的DNa甲基化，组蛋白泛素化和肿瘤抑制基因表达。

ICBP90 Regulation of DNA Methylation, Histone Ubiquitination, and Tumor Suppressor Gene Expression in Breast Cancer Cells.

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