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首页> 外文期刊>Comparative and functional genomics >Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis
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Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis

机译：子宫内膜异位症恶性转化：表观遗传学作为卵巢肿瘤发生的可能机制。

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摘要

Endometriosis, defined as the presence of ectopic endometrial glands and stroma outside the uterine cavity, is a chronic, hormone-dependent gynecologic disease affecting millions of women across the world, with symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dysuria, and subfertility. In addition, there is well-established evidence that, although endometriosis is considered benign, it is associated with an increased risk of malignant transformation, with the involvement of various mechanisms of development. More and more evidence reveals an important contribution of epigenetic modification not only in endometriosis but also in mechanisms of endometriosis malignant transformation, including DNA methylation and demethylation, histone modifications, and miRNA aberrant expressions. In this present review, we mainly summarize the research progress about the current knowledge regarding the epigenetic modifications of the relations between endometriosis malignant transformation and ovarian cancer in an effort to identify some risk factors probably associated with ectopic endometrium transformation.
机译：子宫内膜异位症定义为子宫腔外异位子宫内膜腺体和间质的存在，是一种慢性的，依赖激素的妇科疾病，影响全世界数以百万计的妇女，症状包括慢性骨盆痛，痛经，性交困难，排尿困难和生育力不足。此外，有充分的证据表明，尽管子宫内膜异位症被认为是良性的，但它伴随着各种发展机制而增加了恶性转化的风险。越来越多的证据表明表观遗传修饰不仅在子宫内膜异位症中而且在子宫内膜异位症恶性转化的机制中都具有重要作用，包括DNA甲基化和去甲基化，组蛋白修饰和miRNA异常表达。在本综述中，我们主要概述有关子宫内膜异位症恶变与卵巢癌之间关系的表观遗传学修饰的最新知识的研究进展，以找出可能与异位子宫内膜异位相关的一些危险因素。

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