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首页> 外文期刊>International Journal of Genomics >Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis
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Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis

机译：子宫内膜异位症恶性转化：表皮遗传学作为卵巢肿瘤瘤中可能的机制

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摘要

Endometriosis, defined as the presence of ectopic endometrial glands and stroma outside the uterine cavity, is a chronic, hormone-dependent gynecologic disease affecting millions of women across the world, with symptoms including chronic pelvic pain,dysmenorrhea, dyspareunia, dysuria, and subfertility. In addition, there is well-established evidence that, although endometriosis is considered benign, it is associated with an increased risk of malignant transformation, with the involvement of variousmechanisms of development. More and more evidence reveals an important contribution of epigenetic modification not only in endometriosis ,but also in mechanisms of endometriosis malignant transformation, including DNA methylation and demethylation, histone modifications, and miRNA aberrant expressions. In this present review, we mainly summarize the research progress about the current knowledge regarding the epigenetic modifications of the relations between endometriosis malignant transformation and ovarian cancer in an effort to identify some risk factors probably associated with ectopic endometrium transformation.
机译：子宫内膜异位症，被定义为子宫腔外的异位子宫内膜腺体和基质的存在，是影响全世界数百万妇女的慢性，激素依赖性妇科疾病，症状包括慢性盆腔疼痛，痛经，疑难虑，疑难虑，困难和体育活动。此外，存在既定的证据表明，虽然子宫内膜异位症被认为是良性的，但由于各种机制的发展的危害增加了恶性转型的风险增加。越来越多的证据表明表观遗传修饰不仅在子宫内膜异位症中的重要贡献，而且涉及子宫内膜异位症恶性转化的机制，包括DNA甲基化和去甲基化，组蛋白修饰和miRNA异常表达。在本综述中，我们主要总结了关于目前关于表观症恶性转化和卵巢癌关系的表观遗传修改的研究进展，以确定可能与异位子宫内膜转化相关的一些风险因素。

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