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首页> 外文期刊>Comparative Medicine >Insulin-Induced Hypoglycemic Peripheral Motor Neuropathy in Spontaneously Diabetic WBN/Kob Rats
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Insulin-Induced Hypoglycemic Peripheral Motor Neuropathy in Spontaneously Diabetic WBN/Kob Rats

机译：自发性糖尿病WBN / Kob大鼠的胰岛素诱导的低血糖周围运动神经病

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Intensiveinsulintherapycanleadtohypoglycemia,withpatientssometimesdevelopinghypoglycemicneuropathy.SpontaneouslydiabeticWistarBonnKobori(WBN/Kob)ratsdevelopdiabeticperipheralmotorneuropathycharacterizedbysegmentaldemyelinationandaxonaldegeneration.Weexaminedtheshort-termeffectsofhypoglycemiaonneuropathicchangesintheserats.SpontaneousdiabeticWBN/Kobratsreceivedinsulinimplantsfor40dandweredividedinto3groupsbasedonbloodglucoselevels:groupN,normoglycemictoslightlyhyperglycemic(150to250mg/dL);groupH,hypoglycemictoslightlyhyperglycemic(50to200mg/dL);andgroupD,nontreatedspontaneouslydiabetic(350to420mg/dL).Conductionvelocitywasmeasuredinsciatic#8211;tibialmotornerves;thesenervesalsounderwentqualitativeandquantitativehistomorphologicanalysis.ConductionvelocitywasnotsignificantlydifferentinN,D,andHgroups.MorphologicanalysisofthesciaticnervesofHratsshowedseverechanges,includingaxonaldegeneration,myelindistention,andendoneurialfibrosis,thattendedtooccurinlarge,myelinatedfibers.NandDratsshowedrelativelymildchanges.ThedegreeanddistributionofdegeneratednervefibersinHratsweresignificantlyhigherthaninNandDrats.Theseresultssuggestthathypoglycemiaoflessthan50mg/dLinducedsevereperipheralneuropathy.HypoglycemiclesionsdifferedfromthehyperglycemiclesionsindiabeticWBN/Kobrats.Thisratstrainisanappropriatemodelforinvestigatingthehypoglycemicperipheralneuropathythatcanbeassociatedwithadiabeticcondition.
机译：Intensiveinsulintherapycanleadtohypoglycemia，withpatientssometimesdevelopinghypoglycemicneuropathy.SpontaneouslydiabeticWistarBonnKobori（WBN /赤羚）ratsdevelopdiabeticperipheralmotorneuropathycharacterizedbysegmentaldemyelinationandaxonaldegeneration.Weexaminedtheshort-termeffectsofhypoglycemiaonneuropathicchangesintheserats.SpontaneousdiabeticWBN / Kobratsreceivedinsulinimplantsfor40dandweredividedinto3groupsbasedonbloodglucoselevels：groupN，normoglycemictoslightlyhyperglycemic（150to250mg /分升）; groupH，hypoglycemictoslightlyhyperglycemic（50to200mg /分升）; andgroupD，nontreatedspontaneouslydiabetic（350to420mg / dL）的.Conductionvelocitywasmeasuredinsciatic＃8211胫神经的能量也经过了定性和定量的组织形态学分析。传导速度在N，D和H组中没有显着差异。短时间内温和的变化

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