Aerosolized Bacillus anthracis Infection in New Zealand White Rabbits: Natural History and Intravenous Levofloxacin Treatment

Yee Steven B; Hatkin Joshua M; Dyer David N; Orr Steven A; Pitt M Louise M

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Aerosolized Bacillus anthracis Infection in New Zealand White Rabbits: Natural History and Intravenous Levofloxacin Treatment

机译：新西兰白兔的气溶胶化炭疽芽孢杆菌感染：自然史和静脉注射左氧氟沙星治疗

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ThenaturalhistoryforinhalationalBacillusanthracis(Amesstrain)exposureinNewZealandwhiterabbitswasinvestigatedtobetteridentifypotential,earlybiomarkersofanthrax.TwelveSPFBordetella-freerabbitswereexposedto150LDsubxmlns="http://pub2web.metastore.ingenta.coms/"50/subaerosolizedB.anthracisspores,andclinicalsigns,bodytemperature,completebloodcount,bacteremia,andpresenceofprotectiveantigenintheblood(thatis,antigenemia)wereexamined.Thedevelopmentofantigenemiaandbacteremiacoincidedandprecededbothpyrexiaandinversionoftheheterophil:lymphocyteratio,anindicatorofinfection.Antigenemiawasdeterminedwithin1hbyelectrochemiluminescenceimmunoassay,comparedwiththe24-htraditionalcultureneededforbacteremiadetermination.Rabbitsappearedclinicallynormaluntilshortlybeforesuccumbingtoanthraxapproximately47hafterchallengeorapproximately22hafterantigenemia,whichsuggestsarelativelynarrowtherapeuticwindowofopportunity.Toevaluatethetherapeuticrabbitmodel,B.anthracis-exposedrabbitsweretreated(afterdeterminationofantigenemiaandlaterconfirmedtobebacteremic)intravenouslywiththefluoroquinoloneantibioticlevofloxacinfor5datatotaldailydoseof25or12.5mg/kg,resultinginnearly90%and70%survival,respectively,tothestudyend(28dafterchallenge).Thepeaklevelfor12.5mg/kgwasequivalenttothatobservedfora500-mgdailylevofloxacindoseinhumans.Theseresultssuggestthatintravenouslevofloxacinisaneffectivetherapeuticagainstinhalationalanthrax.Takentogether,ourfindingsindicatethatantigenemiaisaviableandearlybiomarkerforB.anthracisinfectionthatcanbeusedasatreatmenttriggertoallowfortimelyinterventionagainstthishighlypathogenicdisease.

机译：ThenaturalhistoryforinhalationalBacillusanthracis（Amesstrain）exposureinNewZealandwhiterabbitswasinvestigatedtobetteridentifypotential，earlybiomarkersofanthrax.TwelveSPFBordetella-freerabbitswereexposedto150LD 50 aerosolizedB.anthracisspores，andclinicalsigns，bodytemperature，completebloodcount，菌血症，andpresenceofprotectiveantigenintheblood（ thatis，抗原）wereexamined.Thedevelopmentofantigenemiaandbacteremiacoincidedandprecededbothpyrexiaandinversionoftheheterophil：lymphocyteratio，anindicatorofinfection.Antigenemiawasdeterminedwithin1hbyelectrochemiluminescenceimmunoassay，comparedwiththe24-htraditionalcultureneededforbacteremiadetermination.Rabbitsappearedclinicallynormaluntilshortlybeforesuccumbingtoanthraxapproximately47hafterchallengeorapproximately22hafterantigenemia，whichsuggestsarelativelynarrowtherapeuticwindowofopportunity.Toevaluatethetherapeuticrabbitmodel，B.anthracis-exposedrabbitsweretreated（afterdeterminationof antigenemiaandlaterconfirmedtobebacteremic）intravenouslywiththefluoroquinoloneantibioticlevofloxacinfor5datatotaldailydoseof25or12.5mg /千克，resultinginnearly90％and70％的存活率分别tothestudyend（28dafterchallenge）.Thepeaklevelfor12.5mg / kgwasequivalenttothatobservedfora500-mgdailylevofloxacindoseinhumans.Theseresultssuggestthatintravenouslevofloxacinisaneffectivetherapeuticagainstinhalationalanthrax.Takentogether，ourfindingsindicatethatantigenemiaisaviableandearlybiomarkerforB.anthracisinfectionthatcanbeusedasatreatmenttriggertoallowfortimelyinterventionagainstthishighlypathogenicdisease。

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《Comparative Medicine》 |2010年第6期|共页
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Yee Steven B; Hatkin Joshua M; Dyer David N; Orr Steven A; Pitt M Louise M;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Aerosolized Bacillus anthracis infection in New Zealand white rabbits: natural history and intravenous levofloxacin treatment. [J] . Yee S. B., Hatkin J. M., Dyer D. N., Comparative Medicine . 2010,第6期

机译：新西兰白兔的气溶胶化炭疽杆菌感染：自然史和静脉注射左氧氟沙星治疗。
2. Bacillus anthracis Protective Antigen Kinetics in Inhalation Spore-Challenged Untreated or Levofloxacin/Raxibacumab-Treated New Zealand White Rabbits [J] . Alfred Corey, Cecil Chen, Chris Ward, Toxins . 2013,第1期

机译：炭疽芽孢杆菌保护性抗原在吸入孢子挑战的未经治疗或左氧氟沙星/雷珠单抗治疗的新西兰白兔中的动力学
3. Transient Lipopolysaccharide-Induced Resistance to Aerosolized Bacillus anthracis in New Zealand White Rabbits [J] . Yee Steven B., Dyer David N., Twenhafel Nancy A., Comparative Medicine . 2013,第3期

机译：瞬时脂多糖诱导的新西兰白兔对气溶胶芽孢杆菌的抗性
4. SnET2 for the treatment of vascular disease: dose/response study in New Zealand white (NZW) rabbits [C] . Hugh L. Narciso, Jr., PDT, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V . 1995

机译：SnET2治疗血管疾病：新西兰白兔的剂量/反应研究
5. The behavior and social preferences of New Zealand white rabbits. [D] . Chu, Ling-ru. 2003

机译：新西兰白兔的行为和社会偏好。
6. Aerosolized Bacillus anthracis Infection in New Zealand White Rabbits: Natural History and Intravenous Levofloxacin Treatment [O] . Steven B Yee, Joshua M Hatkin, David N Dyer, 2010

机译：新西兰白兔的气溶胶化炭疽芽孢杆菌感染：自然史和静脉注射左氧氟沙星治疗
7. Bacillus anthracis Protective Antigen Kinetics in Inhalation Spore-Challenged Untreated or Levofloxacin/ Raxibacumab-Treated New Zealand White Rabbits [O] . Cecil Chen, Chris Ward, Michele Fiscella, 2013

机译：炭疽杆菌保护性抗原动力学在吸入孢子激发的未经治疗或左氧氟沙星/拉克沙珠单抗治疗的新西兰白兔

Aerosolized Bacillus anthracis Infection in New Zealand White Rabbits: Natural History and Intravenous Levofloxacin Treatment

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