Blood D-(&#8722;)-3-Hydroxybutyrate Concentrations after Oral Administration of Trioctanoin, Trinonanoin, or Tridecanoin to Newborn Rhesus Monkeys (Macaca mulatta)

Tetrick Mark A; Greer Frank R; Benevenga Norlin J

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Blood D-(−)-3-Hydroxybutyrate Concentrations after Oral Administration of Trioctanoin, Trinonanoin, or Tridecanoin to Newborn Rhesus Monkeys (Macaca mulatta)

机译：向新生恒河猴（猕猴）口服给予三辛酸，三壬酸或十三烷酸后的血D-（＆＃8722;）-3-羟丁酸浓度

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Prematurenewborninfantsarebornwithlimitedstoresofglycogenandfat.Energy,suchasmedium-chaintriglycerides(MCT),whichcansparetheuseofbodyproteinasmetabolicenergy,maybebeneficial.ThisstudycomparesMCTcontainingC8,C9,orC10fattyacidsasoralsourcesofenergyfornewbornrhesusmonkeys(Macacamulatta).Onday1oflife,4groupsof5monkeysweregivenasingledoseofwaterorMCTbynasogastrictube.Thedoseprovidedapproximately80%oftheexpectedenergyrequirement.PlasmaC8:0,C9:0,andC10:0fattyacidsandwhole-bloodD-(#8722;)-3-hydroxybutyrate(3HB)concentrationsweremeasuredat0,1,and3hafterdosing.Concentrationsoffreefattyacids(C8,C9,orC10)andketone(3HB)increasedwithtimeafterthedose.At1and3h,concentrationsofC8andC9didnotdiffer,butC9wasgreaterthanC10.At1h,blood3HBconcentrationsduetoC8triglyceridewerehigherthanC9orC10(503versus174and225#59157;mol/Lrespectively).AsMCTchainlengthincreasedfromC8toC10,bloodconcentrationof3HBdecreased.Odd-chainMCT(C9versusC8)resultedinlowerwhole-bloodketone(3HB),perhapsduetoC9metabolismortherateofreleaseoruptakeoffattyacids.TheseresultshaveimplicationsfortheuseofMCTinnutritionalsupplementsforpreterminfants.

机译：Prematurenewborninfantsarebornwithlimitedstoresofglycogenandfat.Energy，suchasmedium-chaintriglycerides（MCT），whichcansparetheuseofbodyproteinasmetabolicenergy，maybebeneficial.ThisstudycomparesMCTcontainingC8，C9，orC10fattyacidsasoralsourcesofenergyfornewbornrhesusmonkeys（Macacamulatta）.Onday1oflife，4groupsof5monkeysweregivenasingledoseofwaterorMCTbynasogastrictube.Thedoseprovidedapproximately80％oftheexpectedenergyrequirement.PlasmaC8：0，C9：0，andC10：0fattyacidsandwhole-bloodD - （＃8722; ）-3-羟基丁酸酯（3HB）concentrationsweremeasuredat0,1，and3hafterdosing.Concentrationsoffreefattyacids（C8，C9，orC10）andketone（3HB）increasedwithtimeafterthedose.At1and3h，concentrationsofC8andC9didnotdiffer，butC9wasgreaterthanC10.At1h，blood3HBconcentrationsduetoC8triglyceridewerehigherthanC9orC10（503versus174and225＃59157;摩尔/ Lrespectively）.AsMCTchainlengthincreasedfromC8toC10，bloodconcentrationof3HBdecreased 。下链全血酮（3HB）产生单链MCT（C9 vs C8），可能是由于C9代谢了释放物的速率这些结果对于使用早产儿的MCT营养补充品具有重要意义。

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《Comparative Medicine》 |2010年第6期|共页
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Tetrick Mark A; Greer Frank R; Benevenga Norlin J;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Blood D-(-)-3-hydroxybutyrate concentrations after oral administration of trioctanoin, trinonanoin, or tridecanoin to newborn rhesus monkeys (Macaca mulatta). [J] . Tetrick M. A., Greer F. R., Benevenga N. J. Comparative Medicine . 2010,第6期

机译：向新生恒河猴（猕猴）口服给予三辛酸，三壬酸或十三烷酸后的血液D-（-）-3-羟基丁酸浓度。
2. Drug-containing gelatin treats as an alternative to gavage for long-term oral administration in rhesus monkeys (Macaca mulatta). [J] . Zhang ShuAng, Ye Bin, Zeng Li, Journal of the American Association for Laboratory Animal Science . 2012,第6期

机译：含药物的明胶可以替代恒河猴长期口服的强饲法（猕猴）。
3. Effect of oral melatonin on plasma growth hormone concentration in rhesus monkeys (Macaca mulatta) [J] . Ghulam Jaffar Kanhar, Samiullah Soomro Pure and Applied Biology . 2021,第4期

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5. Neuroadaptations and behavioral profiles associated with cocaine self-administration in Rhesus monkeys (Macaca mulatta). [D] . Shinday, Nina M. 2013

机译：与可卡因自我给药有关的恒河猴（猕猴）的神经适应和行为特征。
6. Blood D-(–)-3-Hydroxybutyrate Concentrations after Oral Administration of Trioctanoin Trinonanoin or Tridecanoin to Newborn Rhesus Monkeys (Macaca mulatta) [O] . Mark A Tetrick, Frank R Greer, Norlin J Benevenga 2010

机译：新生恒河猴（猕猴）口服给予三辛酸三壬酸或十三烷酸后的血液D-（–）-3-羟基丁酸浓度
7. Population density-dependent hair cortisol concentrations in rhesus monkeys (Macaca mulatta) [O] . A.M. Dettmer, M.A. Novak, J.S. Meyer, 2014

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8. Research and Development Studies Relative to the Experimental Induction of Oral Facial Malformations in the Rhesus Monkey ('Macaca mulatta') [R] . McClure, H. M. 1982

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Blood D-(&#8722;)-3-Hydroxybutyrate Concentrations after Oral Administration of Trioctanoin, Trinonanoin, or Tridecanoin to Newborn Rhesus Monkeys (Macaca mulatta)

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Blood D-(−)-3-Hydroxybutyrate Concentrations after Oral Administration of Trioctanoin, Trinonanoin, or Tridecanoin to Newborn Rhesus Monkeys (Macaca mulatta)