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Peripheral Blood Progenitor Cell Mobilization and Leukapheresis in Pigs

机译：猪外周血祖细胞动员和白细胞分离

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BackgroundandPurpose:Thepigisbeinginvestigatedasanorgandonorforhumans.Inductionofimmunologictolerancetopigtissuesinprimateswouldovercomethemajorimmunologicbarrierstoxenotransplantation.Aprovenmethodofinducingtolerancetoallograftsisbytheinductionofmixedhematopoieticchimerismbybonemarrowtransplantation.Wearethereforeinvestigatinginductionofmixedhematopoieticchimerisminthepig-to-baboonmodel.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Toobtainlargenumbersofpighematopoieticcells,leukapheresiswasusedtocollectbloodcellproductsinminiatureswine(n=5)afterprogenitorcellmobilizationbyuseofacourseofhematopoieticgrowthfactors(cytokines),consistingofporcineinterleukin3,porcinestemcellfactor,andhumangranulocytecolony-stimulatingfactor.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Cytokinetherapyandleukapheresiswerewelltolerated.Cytokinetherapyincreasedthetotalwhitebloodcellcountandallowedlargenumbersofleukocytes(60x10supxmlns="http://pub2web.metastore.ingenta.coms/"10/sup)tobeobtainedbyapheresis,ofwhichapproximately0.1%weregranulocyte-erythrocyte-monocyte-megakaryocytecolony-formingunits(CFUGEMMs),whichareconsideredtoberepresentativeofhematopoieticprogenitorswithmulti-lineagepotential.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:Thecombinationofcytokinetherapyandleukapheresisenableshematopoieticprogenitorcellstobeobtainedsafelyfromminiatureswine.
机译：BackgroundandPurpose：Thepigisbeinginvestigatedasanorgandonorforhumans.Inductionofimmunologictolerancetopigtissuesinprimateswouldovercomethemajorimmunologicbarrierstoxenotransplantation.Aprovenmethodofinducingtolerancetoallograftsisbytheinductionofmixedhematopoieticchimerismbybonemarrowtransplantation.Wearethereforeinvestigatinginductionofmixedhematopoieticchimerisminthepig到baboonmodel 方法：Toobtainlargenumbersofpighematopoieticcells，leukapheresiswasusedtocollectbloodcellproductsinminiatureswine（N = 5）afterprogenitorcellmobilizationbyuseofacourseofhematopoieticgrowthfactors（细胞因子），由猪白细胞介素3，猪干细胞因子和人粒细胞集落刺激因子组成。 pub2web.metastore.ingenta.c om / ns /“> 10 ），其中约有0.1％的血红细胞-红细胞-单核细胞-巨核细胞集落形成单位（CFUGEMMs）被认为是具有多谱系潜能的造血祖细胞的代表。 结论：从小型猪中安全地获得了细胞因子疗法与白细胞结合疗法可使用的造血祖细胞。

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