Radiographic, Histologic, and Cytologic Lesions Associated with Mutations in the Fitness14226SB Locus of Mice

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Radiographic, Histologic, and Cytologic Lesions Associated with Mutations in the Fitness14226SB Locus of Mice

机译：与Fitness14226SB小鼠基因座中的突变相关的放射学，组织学和细胞学病变

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BackgroundandPurpose:Previousinvestigationoffitness1sup4226SB/supmicerevealedgrowthretardationandmicrocytic,hypochromicanemiawithfunctionalirondeficiency.Serumbiochemicalanalysissuggestedprotein-losingenteropathyandliverdysfunction.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Radiographywasdonetoassesslumbarbonelesionsinmicehemizygousforfitness1(fit1)[cfit1sup4226SB/sup/Df(cMod2sh1)sup26DVT/sup]andage-matchedsiblingcontrols[csupch/sup+/csupch/sup+]at40or60daysofage.Macroscopicandmicroscopiclesionswereevaluatedatnecropsy.Bonemarrowwasexaminedcytologicallytoevaluatehematopoieticlesions.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Micehemizygousforfit1hadradiographicallyevidentlumbarvertebralabnormalities,includingvariousdegreesofvertebralbodyfusion,withlossofintervertebraldiskspacesandmild,generalizedosteopenia.Allmutantmicehadscoliosis.Severalmutantmicehadlordosisand/orkyphosisofvariableseverityandmildsubluxationatthelumbosacraljunction.Markedsplenomegalyandmildcardiomegalywereevident,andbonemarrowcolorrangedfromnormaltoslightlypale.Thespleenhadmarkedextramedullaryhematopoiesis;lumbarvertebraecontainedmicroscopiclesionsthatcorrespondedtotheradiographiclesions.Cytologicexaminationofbonemarrowrevealednormocellulartohypocellularstatus,withmildtomoderateerythroidhypoplasiacharacterizedbymildincreaseinthemyeloid-to-erythroidcellratio,decreasedpercentageoferythroidprecursors,andslightincreaseinpercentageofmyeloidprecursorcells.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:Mutationsinfit1directlyorindirectlycausealteration(s)inblood,organsofhematopoiesis(bonemarrow,spleen,andliver),heart,andvertebralcolumn,andsuggestthatthismousemaybeagoodmodelforstudyofscoliosisandrelationshipsbetweenironmetabolismandbonegrowth.

机译：背景与目的：先前的研究结果为1 4226SB 微带血生长迟缓和具有功能性铁缺乏症的小细胞性，低铬血症。 cfit1 4226SB / Df（cMod2sh1） 26DVT ]和与年龄匹配的同级控件[c ch + / c ch +]在40天或60天.Macroscopicandmicroscopiclesionswereevaluatedatnecropsy.Bonemarrowwasexaminedcytologicallytoevaluatehematopoieticlesions 结果：Micehemizygousforfit1hadradiographicallyevidentlumbarvertebralabnormalities，includingvariousdegreesofvertebralbodyfusion，withlossofintervertebraldiskspacesandmild，generalizedosteopenia.Allmutantmicehadscoliosis.Severalmutantmicehadlordosisand / orkyphosisofvariableseverityandmildsubluxationatthelumbosacra ljunction.Markedsplenomegalyandmildcardiomegalywereevident，andbonemarrowcolorrangedfromnormaltoslightlypale.Thespleenhadmarkedextramedullaryhematopoiesis; lumbarvertebraecontainedmicroscopiclesionsthatcorrespondedtotheradiographiclesions.Cytologicexaminationofbonemarrowrevealednormocellulartohypocellularstatus，withmildtomoderateerythroidhypoplasiacharacterizedbymildincreaseinthemyeloid到erythroidcellratio，decreasedpercentageoferythroidprecursors，andslightincreaseinpercentageofmyeloidprecursorcells 结论：Mutationsinfit1directlyorindirectlycausealteration（。 s）血液，造血器官（骨骼，脾脏和肝脏），心脏，椎骨和柱子，建议此小鼠可能是研究铁代谢和骨生长之间脊柱侧弯和关系的好模型。

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《Comparative Medicine》 |1999年第3期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Radiographic, histologic, and cytologic lesions associated with mutations in the fitness1~(4226SB) locus of mice [J] . A. Eric Schultze, Michael F. McEntee, Gregory B. Daniel Laboratory Animal Science . 1999,第3期

机译：与适应性1〜（4226SB）基因座突变相关的放射学，组织学和细胞学病变
2. INCREASED EXPRESSION IN ADIPOCYTES OF OB RNA IN MICE WITH LESIONS OF THE HYPOTHALAMUS AND WITH MUTATIONS AT THE DB LOCUS [J] . Maffei M., Lee GH., Dani C., Proceedings of the National Academy of Sciences of the United States of America . 1995,第15期

机译：下丘脑病变和DB位点突变引起的小鼠OB RNA的脂联素表达增加
3. Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination. [J] . Zan H, Zhang J, Ardeshna S, Autoimmunity . 2009,第2期

机译：易患狼疮的MRL / faslpr / lpr小鼠在免疫球蛋白基因座中显示出增加的AID表达和广泛的DNA损伤，包括缺失和插入：体细胞高突变和类开关DNA重组同时上调。
4. HISTOLOGY-BASED, LESION-SPECIFIC MODELING OF RELATIVE STRESS DISTRIBUTIONS INDICATES PLAQUE RUPTURE UNLIKELY IN MICE [C] . Ian C. Campbell, Daiana Weiss, Renu Virmani, ASME summer bioengineering conference;SBC2012 . 2012

机译：基于组织学的相对应力分布的特定于部位的建模表明小鼠斑块破裂
5. Histological assessment of osteoarthritis lesions in mice. [D] . McNulty, Margaret Ann. 2010

机译：小鼠骨关节炎病变的组织学评估。
6. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. [O] . M Maffei, H Fei, G H Lee, 1995

机译：下丘脑病变和db基因座突变的小鼠中ob RNA的脂肪细胞表达增加。
7. A correlated histological, cytological, and cytochemical study of the tracheobronchial tree and lungs of mice exposed to cigarette smoke. II. Varying responses of major bronchi to cigarette smoke, absence of bronchogenic carcinoma after prolonged exposure, and disappearance of bronchial lesions after cessation of exposure [O] . Cecilie Leuchtenberger, Rudolf Leuchtenberger, William Zebrun, 1960

机译：暴露于香烟烟雾的阴影曲线树和小鼠肺的相关组织，细胞学和细胞化学研究。 II。各大支气管对香烟烟雾的不同反应，延长曝光后缺乏支气管生成的癌，并停止曝光后支气管病变的消失
8. Qualitative Analysis of Mouse Specific-Locus Mutations: Information on Genetic Organization, Gene Expression, and the Chromosomal Nature of Induced Lesions [R] . Russell, L. B. 1982

机译：小鼠特异性基因座突变的定性分析：诱导损伤的遗传组织，基因表达和染色体性质的信息

Radiographic, Histologic, and Cytologic Lesions Associated with Mutations in the Fitness14226SB Locus of Mice

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