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首页> 外文期刊>Comparative Medicine >Model of Staphylococcus aureus Central Venous Catheter-Associated Infection in Rats
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Model of Staphylococcus aureus Central Venous Catheter-Associated Infection in Rats

机译：大鼠金黄色葡萄球菌中心静脉导管相关感染模型

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BackgroundandPurpose:Staphylococcusaureusisanimportantcauseofintravascularcatheter-associatedbacteremia.Wedevelopedaratcentralvenouscatheter(CVC)-associatedinfectionmodeltostudypathogenesisandtreatment.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Asilasticlumen-within-lumencatheterandrodent-restraintjacketweredesigned.Subcutaneouslytunneledcatheterswereinsertedinthejugularveinof20maleSpragueDawleyrats.Twelverats(group1)wereinoculatedwithS.aureusviatheCVC;threerats(group2)wereinoculatedwithS.aureusviathetailvein,fiverats(group3)servedasuninfectedcontrols;andthreerats(group4)wereinoculatedwithS.aureusviathetailveinbutdidnotundergoCVCinsertion.Fivetoeightdaysafterinoculation,animalswereeuthanized,CVCswereasepticallyremoved,andquantitativeculturewasdone.Quantitativeculturealsowasperformedonblood,heart,liver,lungs,andkidneys.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Infection,characterizedbybacteremiaandmetastaticdisease,wasobservedinallratsinoculatedviatheCVCwithasfewas100colony-formingunits(CFU)ofS.aureus.Ratsofgroup2werenotaslikelytodevelopCVC-associatedinfection,andnoneoftheanimalsofgroups3or4developedinfection.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:ThismodelofCVC-associatedinfectionshouldprovesuitableforstudyingpathogenesisandtreatmentofthecondition.
机译：BackgroundandPurpose：Staphylococcusaureusisanimportantcauseofintravascularcatheter-associatedbacteremia.Wedevelopedaratcentralvenouscatheter（CVC）-associatedinfectionmodeltostudypathogenesisandtreatment 方法：Asilasticlumen中之lumencatheterandrodent-restraintjacketweredesigned.Subcutaneouslytunneledcatheterswereinsertedinthejugularveinof20maleSpragueDawleyrats.Twelverats （组1）wereinoculatedwithS.aureusviatheCVC; threerats（组2）wereinoculatedwithS.aureusviathetailvein，fiverats（组3）servedasuninfectedcontrols; andthreerats（组4）wereinoculatedwithS.aureusviathetailveinbutdidnotundergoCVCinsertion.Fivetoeightdaysafterinoculation，animalswereeuthanized，CVCswereasepticallyremoved，andquantitativeculturewasdone.Quantitativeculturealsowasperformedonblood，心脏，肝，肺，andkidneys 结果：感染，细菌血症和转移性疾病的特征，病原体通过带有金黄色葡萄球菌的100个菌落形成单位（CFU）进行分群。第2组蚊子很可能发展与CVC相关的感染，而第3组或第4组动物中没有一个感染。

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