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mRNA 3′ End Processing Factors: A Phylogenetic Comparison

机译:mRNA 3'末端加工因素:系统发育比较

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Almost all eukaryotic mRNAs possess 3′ ends with a polyadenylate (poly(A)) tail. This poly(A) tail is not encoded in the genome but is added by the process of polyadenylation. Polyadenylation is a two-step process, and this process is accomplished by multisubunit protein factors. Here, we comprehensively compare the protein machinery responsible for polyadenylation of mRNAs across many evolutionary divergent species, and we have found these protein factors to be remarkably conserved in nature. These data suggest that polyadenylation of mRNAs is an ancient process.
机译:几乎所有的真核mRNA都具有带有聚腺苷酸(poly(A))尾巴的3'末端。该poly(A)尾巴不在基因组中编码,而是通过聚腺苷酸化过程添加的。聚腺苷酸化是一个两步过程,该过程由多亚基蛋白质因子完成。在这里,我们全面比较了许多进化趋异物种中负责mRNA聚腺苷酸化的蛋白质机制,并且我们发现这些蛋白质因子在自然界中非常保守。这些数据表明,mRNA的聚腺苷酸化是一个古老的过程。

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