Physiological Function of Mycobacterial mtFabD, an Essential Malonyl-CoA:AcpM Transacylase of Type 2 Fatty Acid Synthase FASII, in Yeastmct1ΔCells

AnerGurvitz

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Physiological Function of Mycobacterial mtFabD, an Essential Malonyl-CoA:AcpM Transacylase of Type 2 Fatty Acid Synthase FASII, in Yeastmct1ΔCells

机译：分枝杆菌mtFabD（一种必需的丙二酰辅酶A：AcpM 2型脂肪酸合酶FASII的转酰酶）在Yeastmct1Δ细胞中的生理功能

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Mycobacterium tuberculosismtFabD is an essential malonyl-CoA:AcpM transacylase and is important for vital protein-protein interactions within type 2 fatty acid synthase FASII. mtFabD contacts KasA, KasB, FabH, InhA, and possibly also HadAB, HadBC, and FabG1/MabA. Disruption of mtFabD's interactions during FASII has been proposed for drug development. Here, the gene for a mitochondrially targeted mtFabD was ectopically expressed inSaccharomyces cerevisiaemct1Δmutant cells lacking the corresponding mitochondrial malonyl-CoA transferase Mct1p, allowing the mutants to recover their abilities to respire on glycerol and synthesize lipoic acid. Hence, mtFabD could physiologically function in an environment lacking holo-AcpM or other native interaction partners.

机译：结核分枝杆菌mtFabD是必不可少的丙二酰辅酶A：AcpM转酰酶，对于2型脂肪酸合酶FASII中重要的蛋白质相互作用至关重要。 mtFabD与KasA，KasB，FabH，InhA以及可能的HadAB，HadBC和FabG1 / MabA联系。有人提出在FASII中破坏mtFabD的相互作用来开发药物。在此，针对线粒体靶向的mtFabD的基因在缺少相应线粒体丙二酰-CoA转移酶Mct1p的酿酒酵母中突变表达，从而使这些突变体恢复了在甘油上呼吸和合成硫辛酸的能力。因此，mtFabD可以在缺乏完整AcpM或其他天然相互作用伙伴的环境中生理发挥作用。

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《Comparative and functional genomics》 |2009年第4期|共4页
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1. Purification and characterization of the Mycobacterium tuberculosis FabD(2), a novel malonyl-CoA : AcpM transacylase of fatty acid synthase [J] . Huang YS, Ge J, Zhang HM, Protein Expression and Purification . 2006,第2期

机译：结核分枝杆菌FabD（2），一种新型丙二酰辅酶A：脂肪酸合酶的AcpM转酰基酶的纯化和鉴定
2. The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2 [J] . Aner Gurvitz Molecular Genetics and Genomics . 2009,第4期

机译：基本的分枝杆菌基因fabG1和fabG4编码3-氧代酰基-硫酯还原酶，该酶在2型酵母线粒体脂肪酸合酶中起作用
3. The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2 [J] . Gurvitz A Molecular genetics and genomics: MGG . 2009,第4期

机译：基本的分枝杆菌基因fabG1和fabG4编码3-氧代酰基-硫酯还原酶，该酶在2型酵母线粒体脂肪酸合酶中起作用
4. Silencing of the Fatty Acid Synthase Gene by RNA Interference Inhibits Growth and Induces Apoptosis of LNCaP Prostate Cancer Cells [C] . Ellen De Schrijver, Koen Brusselmans, Walter Heyns, International Symposium on Hormonal Carcinogenesis . 2005

机译：通过RNA干扰沉默脂肪酸合成酶基因抑制生长并诱导LNCAP前列腺癌细胞的凋亡
5. The Making and Breaking of Lipids: The Characterization of the Protein-Protein and Protein-Substrate Interactions and Bioengineering of Type II Fatty Acid Synthases FabA and AcpP and the Structural and Functional Characterization of Iterative Type I Trans-Acting Enoyl-Reductase, LovC Polyketide Synthase. [D] . Nguyen, Chi Hanh Thi. 2014

机译：脂质的产生和断裂：II型脂肪酸合酶FabA和AcpP的蛋白质-蛋白质和蛋白质-底物相互作用的表征和生物工程以及I型迭代反式烯丙基还原酶，LovC聚酮合酶的结构和功能表征。
6. Physiological Function of Mycobacterial mtFabD an Essential Malonyl-CoA:AcpM Transacylase of Type 2 Fatty Acid Synthase FASII in Yeast mct1Δ Cells [O] . Aner Gurvitz 2009

机译：酵母mct1Δ细胞中分枝杆菌mtFabD（2型脂肪酸合酶FASII的必需丙二酰辅酶A：AcpM转酰酶）的生理功能
7. Physiological Function of Mycobacterial mtFabD, an Essential Malonyl-CoA:AcpM Transacylase of Type 2 Fatty Acid Synthase FASII, in Yeast mct1Δ Cells [O] . Gurvitz, Aner 2009

机译：酵母mct1Δ细胞中分枝杆菌mtFabD（2型脂肪酸合酶FASII的必需丙二酰辅酶A：AcpM转酰酶）的生理功能

Physiological Function of Mycobacterial mtFabD, an Essential Malonyl-CoA:AcpM Transacylase of Type 2 Fatty Acid Synthase FASII, in Yeastmct1ΔCells

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