Systemic and Mucosal Antibody Response in Experimental Chlamydia pneumoniae Infection of Mice

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Systemic and Mucosal Antibody Response in Experimental Chlamydia pneumoniae Infection of Mice

机译：实验性肺炎衣原体感染小鼠的全身和粘膜抗体反应。

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Chlamydiapneumoniaeisacommonhumanrespiratorypathogen,andserafrominfectedindividualsrecognizeseveralproteinsofC.pneumoniae.WeproducedC.pneumoniae-specificproteinsinaBacillussubtilisexpressionsystem.WethenusedtheserecombinantC.pneumoniaeproteinsandpurifiedC.pneumoniaeelementarybodiesasantigensinenzymeimmunoassaystoassessthekineticsandproteinspecificityofthesystemicandmucosalantibodyresponsesinducedbyC.pneumoniaeintranasalinfectioninBALB/cmice.Thesystemicantibodiesinmicerecognizedstrong'key'immunogensofChlamydia,Omp2andHsp60,butweaklytargetedtheMOMPprotein,themajorimmunogeninchlamydialspeciesotherthanC.pneumoniae.TheIgAantibodiesinbronchialsecretionsspecificallyrecognizedtheputativesurfaceproteinofC.pneumoniae,Omp4.OurpreliminaryobservationspointtothenecessityoffurthercharacterizationofthemucosalantibodyresponseduringC.pneumoniaeinfection.

机译：Chlamydiapneumoniaeisacommonhumanrespiratorypathogen，andserafrominfectedindividualsrecognizeseveralproteinsofC.pneumoniae.WeproducedC.pneumoniae-specificproteinsinaBacillussubtilisexpressionsystem.WethenusedtheserecombinantC.pneumoniaeproteinsandpurifiedC.pneumoniaeelementarybodiesasantigensinenzymeimmunoassaystoassessthekineticsandproteinspecificityofthesystemicandmucosalantibodyresponsesinducedbyC.pneumoniaeintranasalinfectioninBALB / cmice.Thesystemicantibodiesinmicerecognizedstrong'key'immunogensofChlamydia，Omp2andHsp60，butweaklytargetedtheMOMPprotein，themajorimmunogeninchlamydialspeciesotherthanC.pneumoniae.TheIgAantibodiesinbronchialsecretionsspecificallyrecognizedtheputativesurfaceproteinofC.pneumoniae，Omp4.OurpreliminaryobservationspointtothenecessityoffurthercharacterizationofthemucosalantibodyresponseduringC.pneumoniaeinfection。

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《Comparative Medicine》 |2006年第4期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Systemic and mucosal antibody response in experimental Chlamydia pneumoniae infection of mice [J] . Penttila T, Wahlstrom E, Vuola JM, Comparative Medicine . 2006,第4期

机译：实验性小鼠肺炎衣原体感染的全身和粘膜抗体反应
2. A Peptide Containing T-Cell Epitopes of Chlamydia trachomatis Recombinant MOMP Induces Systemic and Mucosal Antibody Responses in Mice [J] . Murtada A. Taha, Shree R. Singh, Kara Hulett, World Journal of Vaccines . 2011,第4期

机译：含沙眼衣原体重组MOMP T细胞表位的肽诱导小鼠全身和粘膜抗体反应。
3. Exposure to cigarette smoke and Chlamydia pneumoniae infection in mice: Effect on infectious burden, systemic dissemination and cytokine responses: A pilot study [J] . Swati Kumar, Tamar A. Smith-Norowitz, Stephan Kohlhoff, Journal of immunotoxicology. . 2016,第1期

机译：小鼠接触香烟烟雾和肺炎衣原体感染：对感染负担，全身传播和细胞因子反应的影响：一项初步研究
4. The biodegradable polymeric PLA-PEG nanoparticles is an efficient delivery system for a chlamydial M278 mucosal nanovaccine that provides protective systemic and mucosal antibody responses in mice [C] . Richa Verma, Rajnish Sahu, Saurabh Dixit, Annual techconnect world innovation conference expo;Defense techconnect DTS conference;Annual nanotech conference expo;SBIR/STTR innovation conference . 2018

机译：可生物降解的聚合物PLA-PEG纳米颗粒是衣原体M278粘膜纳米疫苗的有效递送系统，可在小鼠中提供保护性全身和粘膜抗体反应
5. The Importance of Local Mucosal Antibodies in Chlamydia trachomatis Infections in Women [D] . Albritton, Hannah L. 2018

机译：妇女沙眼衣原体感染中局部黏膜抗体的重要性
6. The Chlamydia M278 Major Outer Membrane Peptide Encapsulated in the Poly(lactic acid)-Poly(ethylene glycol) Nanoparticulate Self-Adjuvanting Delivery System Protects Mice Against a Chlamydia muridarum Genital Tract Challenge by Stimulating Robust Systemic and Local Mucosal Immune Responses [O] . Richa Verma, Rajnish Sahu, Saurabh Dixit, -1

机译：衣原体M278主要外膜肽封装在聚（乳酸）-聚（乙二醇）纳米颗粒自佐剂递送系统中可通过刺激鲁棒的全身和局部粘膜免疫反应来保护小鼠免于感染衣原体生殖道。
7. A Peptide Containing T-Cell Epitopes of <i>Chlamydia trachomatis</i> Recombinant MOMP Induces Systemic and Mucosal Antibody Responses in Mice [O] . Murtada A. Taha, Shree R. Singh, Kara Hulett, 2011

机译：含有沙眼衣原体/ i的T细胞表位的肽。重组MOMP诱导小鼠的全身和粘膜抗体反应。

Systemic and Mucosal Antibody Response in Experimental Chlamydia pneumoniae Infection of Mice

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