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首页> 外文期刊>Comparative Medicine >Systemic and mucosal antibody response in experimental Chlamydia pneumoniae infection of mice
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Systemic and mucosal antibody response in experimental Chlamydia pneumoniae infection of mice

机译：实验性小鼠肺炎衣原体感染的全身和粘膜抗体反应

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摘要

Chlamydia pneumoniae is a common human respiratory pathogen, and sera from infected individuals recognize several proteins of C. pneumoniae. We produced C. pneumoniae-specific proteins in a Bacillus subtilis expression system. We then used these recombinant C. pneumoniae proteins and purified C. pneumoniae elementary bodies as antigens in enzyme immunoassays to assess the kinetics and protein specificity of the systemic and mucosal antibody responses induced by C. pneumoniae intranasal infection in BALB/c mice. The systemic antibodies in mice recognized strong 'key' immunogens of Chlamydia, Omp2 and Hsp60, but weakly targeted the MOMP protein, the major immunogen in chlamydial species other than C. pneumoniae. The IgA antibodies in bronchial secretions specifically recognized the putative surface protein of C. pneumoniae, Omp4. Our preliminary observations point to the necessity of further characterization of the mucosal antibody response during C. pneumoniae infection.
机译：肺炎衣原体是人类常见的呼吸道病原体，感染者的血清可识别肺炎衣原体的几种蛋白质。我们在枯草芽孢杆菌表达系统中产生了肺炎衣原体特异性蛋白。然后，我们将这些重组肺炎衣原体肺炎衣原体蛋白和纯化的肺炎衣原体肺炎衣原体基本体用作酶免疫测定中的抗原，以评估BALB / c小鼠中由肺炎衣原体鼻内感染诱导的全身和粘膜抗体应答的动力学和蛋白特异性。小鼠的全身抗体识别衣原体，Omp2和Hsp60的强“关键”免疫原，但弱靶向MOMP蛋白，这是除肺炎衣原体以外的衣原体物种的主要免疫原。支气管分泌物中的IgA抗体特异性识别肺炎衣原体的假定表面蛋白Omp4。我们的初步观察结果指出了进一步表征肺炎衣原体感染过程中黏膜抗体应答的必要性。

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