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Persistent Infection with and Serologic Crossreactivity of Three Novel Murine Noroviruses

机译:三种新型鼠诺如病毒的持续感染和血清学交叉反应

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Accordingtoserologictesting,murinenorovirusisthemostprevalentviralpathogenincontemporarylaboratorymice.Previously,murinenorovirus1(MNV-1)wastheonlynorovirusreportedtoinfectresearchmice.Inthisstudy,3novelmurinenorovirusstrains#8212;MNV-2,MNV-3,andMNV-4#8212;wereisolatedfromgeographicallyseparatemouseresearchcolonies.All4murinenorovirusstrainsusedasindividualantigensinmicrospherefluorescentimmunoassaysdisplayedserologiccross-reactivitytoserumfrommiceinoculatedwithMNV-1,MNV-2,MNV-3,orMNV-4.Inaddition,reversetranscriptase#8211;polymerasechainreactionanalysisat8wkpostinoculationdetectedvirusinthefecesandtissuesofallmiceexperimentallyinoculatedwithMNV-2,MNV-3,orMNV-4.Thisfindingsuggeststhatmicecanhaveprolongedfecalsheddingofandcanbecomepersistentlyinfectedwithmurinenoroviruses.
机译:Accordingtoserologictesting,murinenorovirusisthemostprevalentviralpathogenincontemporarylaboratorymice.Previously,murinenorovirus1(MNV-1)wastheonlynorovirusreportedtoinfectresearchmice.Inthisstudy,3novelmurinenorovirusstrains#8212; 2-WNV,WNV-3,4-andMNV#8212; wereisolatedfromgeographicallyseparatemouseresearchcolonies.All4murinenorovirusstrainsusedasindividualantigensinmicrospherefluorescentimmunoassaysdisplayedserologiccross-reactivitytoserumfrommiceinoculatedwithMNV-1,2-WNV,WNV-3,另外,反转录酶#8211;聚合酶链反应分析在实验接种了MNV-2,MNV-3或MNV-4的小鼠粪便和组织落下后接种了8周后检测到了这种病毒。

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