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首页> 外文期刊>Journal of Clinical Microbiology >Census and Analysis of Persistent False-Negative Results in Serological Diagnosis of Human Immunodeficiency Virus Type 1 Group O Infections
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Census and Analysis of Persistent False-Negative Results in Serological Diagnosis of Human Immunodeficiency Virus Type 1 Group O Infections

机译：在人类免疫缺陷病毒1型O组感染的血清学诊断中持续的假阴性结果普查和分析

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摘要

Human immunodeficiency viruses (HIV) have a high level of genetic diversity. The outlier variants of HIV type 1 (HIV-1) group O are distantly related to HIV-1 group M. Their divergence has an impact on serological diagnosis, with a risk of false-negative results. In this study, we report 20 failure cases, involving patients with primary or chronic infection, in France and Cameroon between 2001 and 2008. Our results indicate that some assays detected group O infection much less efficiently than others. Two major reasons for these false-negative results were identified: the presence or absence of a group O-specific antigen (and the designed sequence) for the detection of antibodies and the greater envelope variability of group O than of group M strains. This study highlights the complexity of screening for these divergent variants and the need to evaluate test performance with a large panel of strains, due to the extensive diversity of group O variants.
机译：人类免疫缺陷病毒（HIV）具有很高的遗传多样性。 O型1型艾滋病毒（HIV-1）组的异常值与M型HIV-1组密切相关。它们的差异对血清学诊断有影响，存在假阴性结果的风险。在这项研究中，我们报告了2001年至2008年之间在法国和喀麦隆发生的20例失败案例，涉及原发性或慢性感染患者。我们的结果表明，某些检测方法检测O组感染的效率比其他方法低得多。鉴定出这些假阴性结果的两个主要原因：存在或不存在用于检测抗体的O组特异性抗原（和设计的序列）以及O组比M组菌株具有更大的包膜变异性。这项研究强调了筛选这些不同变异体的复杂性，以及由于O组变异体的广泛多样性，需要评估大量菌株的测试性能。

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