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首页> 外文期刊>Biology Open >Ecdysone signaling induces two phases of cell cycle exit in?Drosophila?cells
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Ecdysone signaling induces two phases of cell cycle exit in?Drosophila?cells

机译：蜕皮激素信号传导在果蝇细胞中诱导细胞周期退出的两个阶段

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During development, cell proliferation and differentiation must be tightly coordinated to ensure proper tissue morphogenesis. Because steroid hormones are central regulators of developmental timing, understanding the links between steroid hormone signaling and cell proliferation is crucial to understanding the molecular basis of morphogenesis. Here we examined the mechanism by which the steroid hormone ecdysone regulates the cell cycle in?Drosophila. We find that a cell cycle arrest induced by ecdysone in?Drosophila?cell culture is analogous to a G2 cell cycle arrest observed in the early pupa wing. We show that in the wing, ecdysone signaling at the larva-to-puparium transition induces Broad which in turn represses the cdc25c phosphatase String. The repression of String generates a temporary G2 arrest that synchronizes the cell cycle in the wing epithelium during early pupa wing elongation and flattening. As ecdysone levels decline after the larva-to-puparium pulse during early metamorphosis, Broad expression plummets, allowing String to become re-activated, which promotes rapid G2/M progression and a subsequent synchronized final cell cycle in the wing. In this manner, pulses of ecdysone can both synchronize the final cell cycle and promote the coordinated acquisition of terminal differentiation characteristics in the wing.
机译：在发育过程中，必须紧密协调细胞的增殖和分化，以确保适当的组织形态发生。由于类固醇激素是发育时间的主要调节剂，因此了解类固醇激素信号传导与细胞增殖之间的联系对于理解形态发生的分子基础至关重要。在这里，我们研究了类固醇激素蜕皮激素调节果蝇细胞周期的机制。我们发现，蜕皮激素在果蝇细胞培养物中诱导的细胞周期阻滞类似于在早期翼中观察到的G2细胞周期阻滞。我们表明，在机翼上，蜕皮激素在幼虫到产褥期的信号转导诱导广泛，进而压制cdc25c磷酸酶字符串。对String的压制会产生临时的G2阻滞，在that翼早期伸长和变平期间，G2阻滞与翼上皮中的细胞周期同步。随着幼虫到产褥期脉冲的蜕皮激素水平在早期变态期间下降，宽表达急剧下降，从而使弦得以重新激活，从而促进了G2 / M的快速发展以及随后机翼中最终同步的细胞周期。以这种方式，蜕皮激素的脉冲既可以使最终细胞周期同步，又可以促进机翼末端分化特征的协调获取。

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