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Bone Effects of Biologic Drugs in Rheumatoid Arthritis

机译：类风湿关节炎的生物药物对骨骼的影响

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Biologic agents used in the treatment of rheumatoid arthritis (RA) are able to reduce both disease activity and radiographic progression of joint disease. These drugs are directed against several proinflammatory cytokines (TNF α , IL-6, and IL-1) which are involved both in the pathogenesis of chronic inflammation and progression of joint structural damage and in systemic and local bone loss typically observed in RA. However, the role of biologic drugs in preventing bone loss in clinical practice has not yet clearly assessed. Many clinical studies showed a trend to a positive effect of biologic agents in preventing systemic bone loss observed in RA. Although the suppression of inflammation is the main goal in the treatment of RA and the anti-inflammatory effects of biologic drugs exert a positive effect on bone metabolism, the exact relationship between the prevention of bone loss and control of inflammation has not been clearly established, and if the available biologic drugs against TNF α , IL-1, and IL-6 can exert their effect on systemic and local bone loss also through a direct mechanism on bone cell metabolism is still to be clearly defined.
机译：用于治疗类风湿关节炎（RA）的生物制剂能够同时降低疾病活动性和关节疾病的放射学进展。这些药物针对几种促炎细胞因子（TNFα，IL-6和IL-1），它们参与慢性炎症的发病机理和关节结构损伤的进展，并参与通常在RA中观察到的全身性和局部性骨丢失。然而，尚未明确评估生物药物在临床实践中预防骨丢失的作用。许多临床研究表明，在预防RA中观察到的生物制剂对预防全身性骨丢失方面具有积极作用的趋势。尽管抑制炎症是RA治疗的主要目标，而生物药物的抗炎作用对骨骼代谢具有积极作用，但尚不清楚在预防骨质流失与控制炎症之间的确切关系，如果抗TNFα，IL-1和IL-6的生物药物能否通过全身骨细胞代谢的直接机制对全身和局部骨质流失发挥作用，还有待进一步明确。

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