• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical & developmental immunology. >Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8 + T-Cell Functions in Esophageal Squamous Cell Carcinoma
【24h】

Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8 + T-Cell Functions in Esophageal Squamous Cell Carcinoma

机译：吲哚胺2,3-双加氧酶参与食管鳞状细胞癌肿瘤浸润性CD8 + T细胞功能的损害

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The indoleamine 2,3-dioxygenase-(IDO-) mediated microenvironment plays an important role in tumor immune escape. However, the inhibitory effects of IDO on the CD8~(+)tumour-infiltrating lymphocytes (CD8~(+)TILs) in esophageal squamous cell carcinoma (ESCC) have not been clarified yet. Here, we found that the level of IDO expression in ESCC tumor specimens correlated with a reduction in the number of CD8~(+)TILs. Patients with high IDO expression and a low number of CD8~(+)TILs had significantly impaired overall survival time. IDO expression and functional enzyme activity in ESCC cell lines could be induced by IFN γ . When exposed to the milieu generated by IDO-expressing Eca109 cells, the CD8~(+)TILs were suppressed in proliferation, and their cytolytic functions against target tumor cells were lost. These results suggested that impairing CD8~(+)TIL functions by IDO expressed in ESCC possibly contributed to the finding that patients with higher IDO expression have more aggressive disease progression and shorter overall survival time.
机译：吲哚胺2，3-二加氧酶-（IDO-）介导的微环境在肿瘤免疫逃逸中起重要作用。但是，IDO对食管鳞状细胞癌（ESCC）的CD8〜（+）肿瘤浸润淋巴细胞（CD8〜（+）TILs）的抑制作用尚不清楚。在这里，我们发现ESCC肿瘤标本中的IDO表达水平与CD8〜（+）TILs数量的减少有关。 IDO表达高且CD8〜（+）TIL数量少的患者显着损害了总生存时间。 IFNγ可诱导ESCC细胞系IDO表达和功能酶活性。当暴露于表达IDO的Eca109细胞产生的环境中时，CD8〜（+）TILs的增殖受到抑制，并且丧失了对靶肿瘤细胞的溶细胞功能。这些结果表明，在ESCC中表达的IDO损害CD8〜（+）TIL功能可能有助于发现具有较高IDO表达的患者具有更强的疾病进展和更短的总生存时间。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号