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首页> 外文期刊>Biology of Mood & Anxiety Disorders >Area-dependent time courses of brain activation during video-induced symptom provocation in social anxiety disorder
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Area-dependent time courses of brain activation during video-induced symptom provocation in social anxiety disorder

机译：在社交焦虑症中视频诱发的症状激怒过程中大脑激活的区域依赖性时程

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Background Previous functional imaging studies using symptom provocation in patients with social anxiety disorder (SAD) reported inconsistent findings, which might be at least partially related to different time-dependent activation profiles in different brain areas. In the present functional magnetic resonance imaging study, we used a novel video-based symptom provocation design in order to investigate the magnitude and time course of activation in different brain areas in 20 SAD patients and 20 healthy controls. Results The disorder-related videos induced increased anxiety in patients with SAD as compared to healthy controls. Analyses of brain activation to disorder-related versus neutral video clips revealed amygdala activation during the first but not during the second half of the clips in patients as compared to controls. In contrast, the activation in the insula showed a reversed pattern with increased activation during the second but not during the first half of the video clips. Furthermore, a cluster in the anterior dorsal anterior cingulate cortex showed a sustained response for the entire duration of the videos. Conclusions The present findings suggest that different regions of the fear network show differential temporal response patterns during video-induced symptom provocation in SAD. While the amygdala is involved during initial threat processing, the insula seems to be more involved during subsequent anxiety responses. In accordance with cognitive models of SAD, a medial prefrontal region engaged in emotional-cognitive interactions is generally hyperactivated.
机译：背景技术先前在社交焦虑症（SAD）患者中使用症状激发进行的功能成像研究报告了不一致的发现，这可能至少部分与不同大脑区域中不同的时间依赖性激活曲线有关。在目前的功能磁共振成像研究中，我们使用了一种新颖的基于视频的症状激发设计，以研究20名SAD患者和20名健康对照者在不同大脑区域的激活程度和时程。结果与健康对照组相比，与疾病相关的视频诱发了SAD患者焦虑的增加。对与异常相关的视频剪辑和中性视频剪辑的大脑激活进行的分析显示，与对照组相比，患者在剪辑的上半段而非下半段杏仁核激活。相反，绝缘体中的激活显示了相反的模式，在视频剪辑的后半段而不是前半段中增强了激活。此外，在整个视频过程中，前背扣带回皮层中的簇显示出持续的响应。结论：目前的发现表明，恐惧网络的不同区域在视频诱发的SAD症状诱发过程中表现出不同的时间响应模式。尽管杏仁核参与了最初的威胁处理，但在随后的焦虑反应中似乎更多地涉及了岛。根据SAD的认知模型，参与情绪-认知相互作用的内侧前额叶区域通常被过度激活。

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