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首页> 外文期刊>Biology of Mood & Anxiety Disorders >Insula response to unpredictable and predictable aversiveness in individuals with panic disorder and comorbid depression
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Insula response to unpredictable and predictable aversiveness in individuals with panic disorder and comorbid depression

机译：恐慌症和合并症患者对不可预测和可预测的厌恶的绝缘反应

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Background Prior studies suggest that hyperactive insula responding to unpredictable aversiveness is a core feature of anxiety disorders. However, no study to date has investigated the neural correlates of unpredictable aversiveness in those with panic disorder (PD) with comorbid major depressive disorder (MDD). The aim of the current study was to examine group differences in neural responses to unpredictable and predictable aversiveness in 41 adults with either 1) current PD with comorbid MDD (PD-MDD), 2) current MDD with no lifetime diagnosis of an anxiety disorder (MDD-only), or 3) no lifetime diagnosis of psychopathology. All participants completed a functional magnetic resonance imaging (fMRI) scan while viewing temporally predictable or unpredictable negative or neutral images. Findings The results indicated that individuals with PD-MDD exhibited greater bilateral insula activation to unpredictable aversiveness compared with controls and individuals with MDD-only (who did not differ). There were no group differences in insula activation to predictable aversiveness. Conclusions These findings add to a growing literature highlighting the role of the insula in the pathophysiology of anxiety disorders.
机译：背景技术先前的研究表明，对不可预测的厌恶反应过度活跃的绝缘体是焦虑症的核心特征。然而，迄今为止，尚无研究调查恐慌症（PD）与合并症重度抑郁症（MDD）患者的不可预测厌恶性的神经相关性。本研究的目的是研究41例成年人的神经反应对不可预测和可预测的厌恶性的群体差异：1）当前的PD合并有MDD（PD-MDD），2）当前的MDD没有终生诊断的焦虑症（仅MDD），或3）无法终生诊断精神病理学。所有参与者均完成了功能性磁共振成像（fMRI）扫描，同时查看了时间可预测或不可预测的负像或中性像。研究结果结果表明，与对照组和仅MDD的个体（无差异）相比，PD-MDD的个体表现出更大的双侧双岛激活至不可预测的厌恶性。在可预测的厌恶行为中，在岛突激活方面没有群体差异。结论这些发现增加了越来越多的文献，这些文献强调了绝缘体在焦虑症的病理生理中的作用。

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