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首页> 外文期刊>Biology of Mood & Anxiety Disorders >Daily stress reactivity and serotonin transporter gene (5-HTTLPR) variation: internalizing responses to everyday stress as a possible transdiagnostic phenotype
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Daily stress reactivity and serotonin transporter gene (5-HTTLPR) variation: internalizing responses to everyday stress as a possible transdiagnostic phenotype

机译：日常应激反应和血清素转运蛋白基因（5-HTTLPR）变异：将对日常应激的反应内化为可能的转诊表型

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Background Recent studies examining the interaction between the 5-HTTLPR locus in the serotonin transporter gene and life stress in predicting depression have yielded equivocal results, leading some researchers to question whether 5-HTTLPR variation indeed regulates depressive responses to stress. Two possible sources of inconsistent data in this literature are imprecise stress assessment methodologies and a restricted focus on depression phenotypes as the outcome of interest, as opposed to transdiagnostic emotional symptoms such as internalizing and externalizing dimensions. The present study aimed to address these critical limitations in prior research by examining how 5-HTTLPR acts in concert with idiographically assessed daily life stress to predict transdiagnostic emotional outcomes. Results One hundred and four healthy young adults genotyped for 5-HTTLPR reported on their life stress exposure and internalizing and externalizing experiences for 14 consecutive days. As hypothesized, daily stress levels were associated with severity of internalizing symptoms, but only for 5-HTTLPR S allele carriers. Additional analyses revealed that these interactive effects of 5-HTTLPR and daily life stress on internalizing symptoms extended to both the distress and fear subdomains of internalizing symptoms. Conclusions Considered together, these results support the validity of the 5-HTTLPR stress sensitivity hypothesis and suggest for the first time that variation at 5-HTTLPR moderates the effects of daily life stress on broadband symptom profiles.
机译：背景技术最近研究研究5-羟色胺转运蛋白基因中的5-HTTLPR基因座与预测抑郁症的生活压力之间的相互作用产生了模棱两可的结果，导致一些研究人员质疑5-HTTLPR变异是否确实调节了对压力的抑郁反应。文献中数据不一致的两个可能来源是压力评估方法不精确，以及将抑郁表型作为关注的结果，而与诸如内在化和外在化等经诊断性情感症状相反。本研究旨在通过检查5-HTTLPR如何与具体评估的日常生活压力协同作用以预测经转诊的情绪结果来解决先前研究中的这些关键限制。结果104名健康的5-HTTLPR基因型的成年人连续14天报告了他们的生活压力暴露以及内在和外在的经历。如假设的那样，每日压力水平与内部化症状的严重程度相关，但仅针对5-HTTLPR S等位基因携带者。进一步的分析表明，5-HTTLPR和日常生活压力对内在症状的这些交互作用扩展到内在症状的困扰和恐惧子域。结论综上所述，这些结果支持了5-HTTLPR应激敏感性假设的有效性，并首次表明5-HTTLPR的变化减轻了日常生活压力对宽带症状的影响。

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