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Spontaneous Ophthalmic Lesions in Young Swiss Mice

机译：瑞士青年小鼠的自发性眼科病变

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BackgroundandPurpose:Outbredmicearefrequentlyusedintoxicityevaluation.Duetotheirsmallsize,ophthalmologicexaminationofsuchanimalsisdifficultwithregardtorestraintanduseofinstrumentsdesignedforhumanmedicine.Theclinicalappearanceandincidenceofspontaneousophthalmiclesionsshouldbehelpfulinselectingmicefortoxicitystudiesandallowdistinctionbetweenintercurrentspontaneousocularchangesandthoseattributabletodrugsorchemicals.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Pretestophthalmologicexaminationsofabout3,0004-to5-week-oldSwissmice,Crl:CD1?(ICR)BR,conductedin1995and1996,providedinformationaboutspontaneousocularchangesandtheirincidence.Eyeevaluationswereperformedafterpupildilatation(0.5%tropicamideinstillation),usingindirectophthalmoscopy,andwhenindicated,aportableslitlamp.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Lenticularopacitiesandheterogeneity/prominencewerethemostcommonfindings(upto19%)intheanteriorsegment.Abnormalitiesofthecorneaandirisweredetectedinupto4%ofmice.Hyaloidarteryremnant,aswellasisolatedcasesoffloatingbodiesorhemorrhage,wasobservedinthevitreousof12to17%ofmice.Approximately2to4%ofmicehadcolobomatousfundus,retinalfold,orretinalatrophy.Afewmicehadchorioretinalatrophy,hemorrhage,orabnormalpatternoftheretinalvasculature.Remainingfindingsconsistedofincompletepalpebralfissure,microphthalmia,exophthalmia,ophthalmichemorrhage,andscleralmass.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:Duetoseverityoftheconditionorinterferencewithocularexamination,affectedmiceshouldbeeliminatedfromexperimentalstudies.Hence,pretestocularexaminationsofmiceareindicatedinsafetyassessmenttoxicitystudies.
机译：BackgroundandPurpose：Outbredmicearefrequentlyusedintoxicityevaluation.Duetotheirsmallsize，ophthalmologicexaminationofsuchanimalsisdifficultwithregardtorestraintanduseofinstrumentsdesignedforhumanmedicine.Theclinicalappearanceandincidenceofspontaneousophthalmiclesionsshouldbehelpfulinselectingmicefortoxicitystudiesandallowdistinctionbetweenintercurrentspontaneousocularchangesandthoseattributabletodrugsorchemicals 方法：Pretestophthalmologicexaminationsofabout3,0004-TO5周oldSwissmice，CRL：CD1？ （ICR）BR，于1995年和1996年进行，提供了有关自发眼球变化及其发生率的信息。瞳孔扩大后（0.5％热带酰胺滴注），在间接检眼镜的情况下，并在指示的情况下，使用可调节的裂隙灯，对眼睛进行了眼力评估。突出是前段中最常见的发现（高达19％）。角膜和虹膜异常ctedinupto4％ofmice.Hyaloidarteryremnant，aswellasisolatedcasesoffloatingbodiesorhemorrhage，wasobservedinthevitreousof12to17％ofmice.Approximately2to4％ofmicehadcolobomatousfundus，retinalfold，orretinalatrophy.Afewmicehadchorioretinalatrophy，出血，orabnormalpatternoftheretinalvasculature.Remainingfindingsconsistedofincompletepalpebralfissure，小眼球，眼球突出，ophthalmichemorrhage，andscleralmass 结论：由于条件的严重性或对眼科检查的干扰，应从实验研究中消除受影响的小鼠。因此，在安全性评估中应指出小鼠眼前检查的毒性研究。

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