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首页> 外文期刊>Comparative Medicine >Rhesus Monkey (Macaca mulatta) Model of Helicobacter pylori: Noninvasive Detection and Derivation of Specific-Pathogen-Free Monkeys
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Rhesus Monkey (Macaca mulatta) Model of Helicobacter pylori: Noninvasive Detection and Derivation of Specific-Pathogen-Free Monkeys

机译：幽门螺杆菌的恒河猴（猕猴）模型：无特定病原体猴子的无创检测和派生。

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BackgroundandPurpose:DevelopmentoftherhesusmonkeymodelofHelicobacterpylorihasbeenhamperedbyproblemswithserodetectionandbythedifficultyofidentifyingspecific-pathogen(Helicobacter)-freeanimals.Ourpurposewastodeterminewhetherdetectioncouldbeimprovedandtodetermineifpathogen-freemonkeyscouldbederivedbynurseryrearing.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Anenzyme-linkedimmunoabsorbentassay(ELISA)anda[supxmlns="http://pub2web.metastore.ingenta.coms/"14/supC]ureabreathtestwerecomparedtoendoscopytodetermineH.pyloriinfectionstatusinrhesusmacaques;18animalswerehandraisedinthenurserytodeterminewhetherpathogen-freeanimalscouldbeselected.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Helicobacterpyloriinfectionwascommonincolony-raisedyoungrhesusmonkeysandwasnearlyuniversalbyadulthood.Serodetection,usingantigenfromrhesus-derivedH.pyloristrains,was95%sensitiveand94%specific.The[supxmlns="http://pub2web.metastore.ingenta.coms/"14/supC]ureabreathtestwas96%sensitiveand88%specificfordetectionofchronicHelicobacterinfectioninrhesusmonkeys.Segregationofnewbornanimalswithinthefirst24hoflifewasareliablemethodtoobtainpathogen-freerhesusmonkeys.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusion:Isolationofspecific-pathogen-freeanimals,togetherwithbetterdetectionmethods,mayimprovethevalueoftherhesusmonkeymodelforthestudyofH.pyloripathogenesis,immuneresponse,andvaccinedevelopment.
机译：BackgroundandPurpose：DevelopmentoftherhesusmonkeymodelofHelicobacterpylorihasbeenhamperedbyproblemswithserodetectionandbythedifficultyofidentifyingspecific - 病原体（幽门螺杆菌）-freeanimals.Ourpurposewastodeterminewhetherdetectioncouldbeimprovedandtodetermineifpathogen-freemonkeyscouldbederivedbynurseryrearing 方法：Anenzyme-linkedimmunoabsorbentassay（ELISA）安达[<我们比较了内窥镜检查确定H.pyloriinfectionstatusinrhesus猕猴的能力;比较了18种动物是否可以通过published来选择http：//pub.ns.html。 ns /“> 结果：成年幽门螺杆菌感染是常见的菌落，幼年几乎普遍存在。使用源自rhesus的H.pyloristrains抗原进行血清检测，灵敏度为95％，特异性为94％。[ C] ureabreatht estwas96％sensitiveand88％specificfordetectionofchronicHelicobacterinfectioninrhesusmonkeys.Segregationofnewbornanimalswithinthefirst24hoflifewasareliablemethodtoobtainpathogen-freerhesusmonkeys 结论：Isolationofspecific病原体freeanimals，togetherwithbetterdetectionmethods，mayimprovethevalueoftherhesusmonkeymodelforthestudyofH.pyloripathogenesis，免疫反应，疫苗的发展。

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