Bacterial Lipopolysaccharide Induces a Conduction Block in the Sciatic Nerves of Rats

Brown Rhonda F.; Jackson Graham D. F.; Martin Thomas; Westbrook R. Fred; Pollard John D.; Westland Kornelius W.

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Bacterial Lipopolysaccharide Induces a Conduction Block in the Sciatic Nerves of Rats

机译：细菌脂多糖诱导大鼠坐骨神经传导阻滞

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AsingleinjectionofEscherichiacolilipopolysaccharide(LPS;intraperitoneally[i.p.]andintravenously[i.v.])reliablyinducesperipheralnervedisturbancesinthehindlimbsofinbredAustralianalbinoWistar(AaW)rats.Intheseriesofexperimentspresentedhere,weaimedtocharacterizethissyndromebyexaminingelectrophysiologic,immunologic,andimmunochemicalfeatures.TheLPS-inducedneurologicsequelaeinAaWratsweretransient,atleastpartlyreversiblebydrugtreatment,andwerenotassociatedwithanydetectableneuropathologicfindingsbylightmicroscopy.Neurologicsequelaewerepreventedbyadministrationofdexamethasoneandbypretreatmentwiththemacrophageinhibitorgadoliniumchloride,suggestingthattheywerecausedbyLPS-inducedactivationofperipheralmacrophages.Sequelaewereassociatedwithearlydecreasesincompoundmuscle-actionpotentialamplitudes,indicatingimpairedfunctioningofeitherproximalsciaticnerveaxonsand/orneuromuscularsynapses.Spinalsomatosensory-evokedpotentiallatenciesalsowereincreased,indicatingimpairedsomatosensoryfunctionatthesciaticnerve,dorsalroots,spinalcord,and/orpostsynapticinterneurons,althoughthepreciselocationofimpairmentcouldnotbedelineated.Similaritiesbetweenthissyndromeandimmune-mediatedpolyneuropathiesinhumansarediscussed.

机译：AsingleinjectionofEscherichiacolilipopolysaccharide（LPS;腹膜内[IP] andintravenously [IV]）reliablyinducesperipheralnervedisturbancesinthehindlimbsofinbredAustralianalbinoWistar（AAW）rats.Intheseriesofexperimentspresentedhere，weaimedtocharacterizethissyndromebyexaminingelectrophysiologic，免疫，andimmunochemicalfeatures.TheLPS-inducedneurologicsequelaeinAaWratsweretransient，atleastpartlyreversiblebydrugtreatment，andwerenotassociatedwithanydetectableneuropathologicfindingsbylightmicroscopy.Neurologicsequelaewerepreventedbyadministrationofdexamethasoneandbypretreatmentwiththemacrophageinhibitorgadoliniumchloride，suggestingthattheywerecausedbyLPS-inducedactivationofperipheralmacrophages.Sequelaewereassociatedwithearlydecreasesincompoundmuscle-actionpotentialamplitudes，indicatingimpairedfunctioningofeitherproximalsciaticnerveaxonsand / orneuromuscularsynapses.Spinalsomatosensory诱发的潜在潜伏期也增加了，表明坐骨神经的躯体感觉功能受损，尽管无法准确描述损伤的确切位置，但背面根，脊索和/或突触后神经元都在讨论中。讨论了该综合征与人类免疫介导的多神经病之间的相似之处。

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《Comparative Medicine》 |1999年第1期|共页
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Brown Rhonda F.; Jackson Graham D. F.; Martin Thomas; Westbrook R. Fred; Pollard John D.; Westland Kornelius W.;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Bacterial lipopolysaccharide induces a conduction block in the sciatic nerves of rats [J] . Rhonda F. Brown, Graham D. F. Jackson, Thomas Martin Laboratory Animal Science . 1999,第1期

机译：细菌脂多糖诱导大鼠坐骨神经传导阻滞
2. Synthesis of new chiral xanthone derivatives acting as nerve conduction blockers in the rat sciatic nerve [J] . FernandesC., OliveiraL., TiritanM.E., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2012,第Null期

机译：新型手性黄酮酮衍生物在大鼠坐骨神经中作为神经传导阻滞剂的合成
3. Synthesis of new chiral xanthone derivatives acting as nerve conduction blockers in the rat sciatic nerve [J] . FernandesC., OliveiraL., TiritanM.E., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2012,第Null期

机译：新的手性X吨酮衍生物的合成，作用为大鼠坐骨神经中神经传导阻滞剂
4. Quantification of Neural Conduction Block on the Rat Sciatic Nerve based on EMG Response [C] . Diego Pérez, Gabriel Dieuset, Maxime Yochum, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：基于EMG响应的大鼠坐骨神经神经传导阻滞的量化
5. The minimum effective dose of lidocaine needed to block evoked potentials in the sciatic nerve of the rat. [D] . Stelflug, Bradley Wayne. 1998

机译：阻断大鼠坐骨神经诱发电位所需的最小利多卡因有效剂量。
6. Inhibitory effects of forskolin and papaverine on nerve conduction partially blocked by tetrodotoxin in the frog sciatic nerve. [O] . J. A. Ribeiro, A. M. Sebastião 1985

机译：福司可林和罂粟碱对青蛙坐骨神经中河豚毒素的神经传导有部分抑制作用。
7. Nerve Conduction Blockade in the Sciatic Nerve Prevents but Does Not Reverse the Activation of p38 Mitogen-activated Protein Kinase in Spinal Microglia in the Rat Spared Nerve Injury Model [O] . Yeong-Ray Wen, Marc R. Suter, Yasuhiko Kawasaki, 2007

机译：坐骨神经中的神经传导阻断阻止，但在大鼠粪便神经损伤模型中，不逆转P38丝裂剂活化蛋白激酶的激活

Bacterial Lipopolysaccharide Induces a Conduction Block in the Sciatic Nerves of Rats

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