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首页> 外文期刊>Biology Open >Hindsight/RREB-1 functions in both the specification and differentiation of stem cells in the adult midgut of Drosophila
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Hindsight/RREB-1 functions in both the specification and differentiation of stem cells in the adult midgut of Drosophila

机译：Hindsight / RREB-1在果蝇成年中肠干细胞的规格和分化中均起作用

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The adult Drosophila midgut is established during the larval/pupal transition from undifferentiated cells known as adult midgut precursors (AMPs). Four fundamental cell types are found in the adult midgut epithelium: undifferentiated intestinal stem cells (ISCs) and their committed daughter cells, enteroblasts (EBs), plus enterocytes (ECs) and enteroendocrine cells (EEs). Using the Drosophila posterior midgut as a model, we have studied the function of the transcription factor Hindsight (Hnt)/RREB-1 and its relationship to the Notch and Egfr signaling pathways. We show that hnt is required for EC differentiation in the context of ISC-to-EC differentiation, but not in the context of AMP-to-EC differentiation. In addition, we show that hnt is required for the establishment of viable or functional ISCs. Overall, our studies introduce hnt as a key factor in the regulation of both the developing and the mature adult midgut. We suggest that the nature of these contextual differences can be explained through the interaction of hnt with multiple signaling pathways.
机译：成年果蝇中肠是在幼虫/ pu转化过程中从未分化的细胞（称为成年中肠前体（AMPs））建立的。在成年中肠上皮细胞中发现了四种基本细胞类型：未分化的肠干细胞（ISC）及其定型子细胞，成肠细胞（EBs），肠上皮细胞（ECs）和肠内分泌细胞（EEs）。使用果蝇后中肠作为模型，我们研究了转录因子Hindsight（Hnt）/ RREB-1的功能及其与Notch和Egfr信号通路的关系。我们表明，hnt是在ISC到EC分化的背景下进行EC分化所必需的，而不是在AMP到EC分化的背景下进行。此外，我们表明建立可行或功能性ISC所需的hnt。总体而言，我们的研究将hnt作为调节发育中和成年中肠的关键因素。我们建议可以通过hnt与多个信号通路的相互作用来解释这些上下文差异的性质。

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