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首页> 外文期刊>Biology Open >Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection
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Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection

机译：在新的大规模回盲肠切除术小鼠模型中，肠道对维生素B12和胆汁酸吸收的适应性不同

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Ileocecal resection (ICR), one of several types of intestinal resection that results in short bowel syndrome (SBS), causes severe clinical disease in humans. We here describe a mouse model of massive ICR in which 75% of the distal small intestine is removed. We demonstrate that mice underwent 75% ICR show severe clinical signs and high mortality, which may recapitulate severe forms of human SBS, despite an adaptive response throughout the remnant intestine. By using this model, we also investigated whether the epithelium of the remnant intestine shows enhanced expression of factors involved in region-specific functions of the ileum. Cubn mRNA and its protein product, which play an essential role in vitamin B12 absorption in the ileum, are not compensatory up-regulated in any part of the remnant intestine, demonstrating a clear contrast with post-operative up-regulation of genes involved in bile acid absorption. Our study suggests that functional adaptation by phenotypical changes in the intestinal epithelium is not a general feature for nutrient absorption systems that are confined to the ileum. We also propose that the mouse model developed in this study will become a unique system to facilitate studies on SBS with ICR in humans.
机译：盲肠切除术（ICR）是导致短肠综合征（SBS）的几种肠切除术之一，它会导致人类严重的临床疾病。我们在这里描述了大型ICR的小鼠模型，其中远端小肠的75％被去除了。我们证明，接受75％ICR的小鼠显示出严重的临床体征和高死亡率，尽管在整个残肠中都有适应性反应，但它们可能概括了人类SBS的严重形式。通过使用该模型，我们还调查了残留肠的上皮是否显示出回肠区域特定功能中涉及的因子的增强表达。在回肠中维生素B12吸收中起重要作用的Cubn mRNA及其蛋白产物在残余肠的任何部分均没有补偿性上调，这与术后胆汁中基因的上调形成明显对比酸吸收。我们的研究表明，肠上皮表型变化引起的功能适应不是局限于回肠的营养吸收系统的普遍特征。我们还建议在此研究中开发的小鼠模型将成为一个独特的系统，以促进对具有ICR的SBS的研究。

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