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首页> 外文期刊>Biology Open >The ATPase TER94 regulates Notch signaling during Drosophila wing development
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The ATPase TER94 regulates Notch signaling during Drosophila wing development

机译：ATPase TER94在果蝇翅膀发育过程中调节Notch信号传导

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摘要

The evolutionarily conserved Notch signaling pathway plays crucial roles in various developmental contexts. Multiple mechanisms are involved in the regulation of Notch pathway activity. Identified through a genetic mosaic screen, we show that the ATPase TER94 acts as a positive regulator of Notch signaling duringDrosophilawing development. Depletion of TER94 causes marginal notches in the adult wing and the reduction of Notch target geneswinglessandcutduring wing margin formation. We provide evidence that TER94 is likely required for proper Notch protein localization and activation. Furthermore, we show that knockdown of the TER94 adaptor p47 leads to similar Notch signaling defects. Although the TER94 complex is implicated in various cellular processes, its role in the regulation of Notch pathways was previously uncharacterized. Our study demonstrates that TER94 positively regulates Notch signaling and thus reveals a novel role of TER94 in development.This article has an associated First Person interview with the first author of the paper.
机译：进化上保守的Notch信号通路在各种发育环境中都起着至关重要的作用。 Notch途径活性的调节涉及多种机制。通过遗传镶嵌屏幕鉴定，我们表明在果蝇加工过程中，ATPase TER94充当Notch信号的正调节剂。 TER94的耗竭会导致成年机翼的边缘切迹，而机翼边缘形成过程中无切翼和切尾的Notch目标基因减少。我们提供证据，TER94可能需要适当的Notch蛋白定位和激活。此外，我们表明，敲除TER94接头p47会导致类似的Notch信号缺陷。尽管TER94复合物与各种细胞过程有关，但其在Notch途径调控中的作用以前并未被表征。我们的研究表明TER94正调控Notch信号传导，从而揭示了TER94在发育中的新作用。本文与第一作者相关的第一人称访谈。

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