Secretory Leukocyte Protease Inhibitor Inhibits Infection of Monocytes and Lymphocytes with Human Immunodeficiency Virus Type 1 but Does Not Interfere with Transcytosis of Cell-Associated Virus across Tight Epithelial Barriers

Hakim Hocini; Pierre Becquart; Hicham Bouhlal; Homa Adle-Biassette; Michel D. Kazatchkine; Laurent Bélec

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Secretory Leukocyte Protease Inhibitor Inhibits Infection of Monocytes and Lymphocytes with Human Immunodeficiency Virus Type 1 but Does Not Interfere with Transcytosis of Cell-Associated Virus across Tight Epithelial Barriers

机译：分泌型白细胞蛋白酶抑制剂抑制人免疫缺陷病毒1型感染单核细胞和淋巴细胞，但不会干扰紧密结合的上皮屏障的细胞相关病毒的转胞作用

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In the present study, we demonstrate that recombinant human secretory leukocyte protease inhibitor (rhSLPI) inhibits infection of lymphocyte- and monocyte-derived tumor cell lines and peripheral blood lymphocytes with laboratory-adapted isolates and with the primary isolate, NDK, of free human immunodeficiency virus type 1 (HIV-1). In contrast, rhSLPI did not exhibit inhibitory activity toward transcytosis of cell-associated HIV-1 through a tight monolayer of endometrial epithelial cells. These observations indicate that the inhibitory effect of SLPI is restricted to free HIV-1 in corporal fluids.

机译：在本研究中，我们证明了重组人分泌型白细胞蛋白酶抑制剂（rhSLPI）可以抑制淋巴细胞和单核细胞衍生的肿瘤细胞系和外周血淋巴细胞感染，其具有实验室适应性分离株和游离人免疫缺陷的主要分离株NDK。 1型病毒（HIV-1）。相反，rhSLPI没有通过紧密的单层子宫内膜上皮细胞对细胞相关HIV-1的胞吞作用表现出抑制活性。这些观察结果表明SLPI的抑制作用限于体液中的游离HIV-1。

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《Clinical and diagnostic laboratory immunology》 |2000年第3期|共4页
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Hakim Hocini; Pierre Becquart; Hicham Bouhlal; Homa Adle-Biassette; Michel D. Kazatchkine; Laurent Bélec;
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1. Cervicovaginal secretory antibodies to human immunodeficiency virus type 1 (HIV-1) that block viral transcytosis through tight epithelial barriers in highly exposed HIV-1-seronegative African women. [J] . Belec L, Ghys PD, Hocini H, The Journal of Infectious Diseases . 2001,第11期

机译：抗人类免疫缺陷病毒1型（HIV-1）的宫颈阴道分泌抗体可在高度暴露的HIV-1阴性女性中通过严密的上皮屏障阻止病毒转细胞作用。
2. Human immunodeficiency virus type-1 Tat protein induces secretory leukocyte protease inhibitor expression in African green monkey but not human cells [J] . Ozdemir Selcuk, Sengez Burcu, Arslanoglu Alper Virus Genes . 2020,第2期

机译：人类免疫缺陷病毒型1 TAT蛋白诱导非洲绿猴但不是人细胞的分泌白细胞蛋白酶抑制剂表达
3. Herpes simplex virus downregulation of secretory leukocyte protease inhibitor enhances human papillomavirus type 16 infection [J] . Joseph G. Skeate^1?4?, Tania B. Porras^1?, Andrew W. Woodham^1?, The Journal of general virology . 2016,第2期

机译：单纯疱疹病毒下调分泌型白细胞蛋白酶抑制剂可增强人乳头瘤病毒16型感染
4. Susceptibility to a non-conventional (folding) protease inhibitor of human immunodeficiency virus Type 1 isolates in vitro [C] . S. RUSCONI, M. Lo CICERO, S. FERRAMOSCA, International School of Physics "Enrico Fermi" . 2007

机译：对人免疫缺陷病毒的非常规（折叠）蛋白酶抑制剂的易感性在体外1型分离物
5. Differential stimulation of monocytes to secrete Secretory Leukocyte Protease Inhibitor by lipopolysaccharide of periodontal pathogens [D] . Primm, Jason Todd 2009

机译：牙周病原体脂多糖对单核细胞的差异刺激以分泌分泌型白细胞蛋白酶抑制剂
6. Note: Secretory Leukocyte Protease Inhibitor Inhibits Infection of Monocytes and Lymphocytes with Human Immunodeficiency Virus Type 1 but Does Not Interfere with Transcytosis of Cell-Associated Virus across Tight Epithelial Barriers [O] . Hakim Hocini, Pierre Becquart, Hicham Bouhlal, 2000

机译：注意：分泌型白细胞蛋白酶抑制剂可抑制人免疫缺陷病毒1型感染单核细胞和淋巴细胞但不会干扰紧密结合的上皮屏障的细胞相关病毒的胞吞作用
7. Secretory Leukocyte Protease Inhibitor Inhibits Infection of Monocytes and Lymphocytes with Human Immunodeficiency Virus Type 1 but Does Not Interfere with Transcytosis of Cell-Associated Virus across Tight Epithelial Barriers [O] . Hocini, Hakim, Becquart, Pierre, Bouhlal, Hicham, 2000

机译：分泌型白细胞蛋白酶抑制剂抑制人免疫缺陷病毒1型感染单核细胞和淋巴细胞，但不会干扰紧密结合的上皮屏障的细胞相关病毒的胞吞作用

Secretory Leukocyte Protease Inhibitor Inhibits Infection of Monocytes and Lymphocytes with Human Immunodeficiency Virus Type 1 but Does Not Interfere with Transcytosis of Cell-Associated Virus across Tight Epithelial Barriers

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