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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Levels of Recent Thymic Emigrant Cells Decrease in Children Undergoing Partial Thymectomy during Cardiac Surgery
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Levels of Recent Thymic Emigrant Cells Decrease in Children Undergoing Partial Thymectomy during Cardiac Surgery

机译：心脏手术过程中部分胸腺切除术患儿的胸腺移出细胞的水平下降

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The human thymus is required for establishment of a T-cell pool in fetal life, but postnatal thymectomy is not known to cause immunodeficiency. T-cell emigration from thymus (thymic recent emigrants [TRECs]) is a continuous thymic-dependent process. We studied TREC levels pre- and post-partial thymectomy in children undergoing cardiac surgery. TRECs were quantitated by real-time PCR in peripheral blood lymphocytes of 24 children (0 to 12 years). TREC values were 47916 ± 9271 pre-partial thymectomy and 33157 ± 8479 post-partial thymectomy in 11 paired patients (P = 0.014). Interval between pre- and post-partial thymectomy was 8.8 days ± 5.8 days. Another group of 8 children had 30384 ± 9748 TRECs 16 days to 6 years post-partial thymectomy. There was a significant drop in TREC values post-partial thymectomy in the immediate postoperative period compared to prethymectomy TREC levels. While decreased thymic output may persist, the long-term implications were not evaluated in this patient population.
机译：在胎儿生命中建立T细胞库需要人胸腺，但不知道产后胸腺切除会引起免疫缺陷。从胸腺（胸腺最近的移民[TRECs]）的T细胞迁移是一个连续的胸腺依赖性过程。我们研究了接受心脏手术的儿童在部分胸腺切除术前后的TREC水平。通过实时PCR对24名儿童（0至12岁）的外周血淋巴细胞中的TRECs进行定量。 11对配对患者的TREC值分别为部分胸腺切除前47916±9271和部分胸腺切除后33157±8479（ P = 0.014）。胸腺部分切除前后的间隔为8.8天±5.8天。另一组8名儿童在部分胸腺切除术后16天至6年内有30384±9748 TRECs。与胸腺切除术前TREC水平相比，部分胸腺切除术后TREC值显着下降。虽然胸腺输出量下降可能会持续，但未对该患者人群的长期影响进行评估。

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