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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Comparison of saliva and serum for human immunodeficiency virus type 1 antibody testing in Uganda using a rapid recombinant assay.
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Comparison of saliva and serum for human immunodeficiency virus type 1 antibody testing in Uganda using a rapid recombinant assay.

机译：使用快速重组测定法比较乌干达的唾液和血清用于人类免疫缺陷病毒1型抗体的检测。

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The accuracy and acceptability of saliva human immunodeficiency virus type 1 (HIV-1) antibody testing were compared with serum testing in a study of paired specimens from HIV-1-seropositive and HIV-1-seronegative Ugandan adults attending a clinic for sexually transmitted diseases. Saliva collection was performed with the Omni-sal device (Saliva Diagnostic Systems, Vancouver, Wash.), and antibody testing was performed by a rapid filter paper assay (Test-Pack; Abbott Laboratories, Abbott Park, Ill.). Relative to serum testing, the sensitivity of saliva testing was 95% (195 of 205) and the specificity was 99% (295 of 297). The sensitivity of saliva testing was higher for patients with elevated levels of beta-2 microglobulin in sera and greater numbers of HIV-1-related symptoms. Pre- and poststudy interviews indicated that saliva testing did not foster inordinate fears of saliva exposure. The development of saliva tests that are inexpensive and do not require electricity is needed.
机译：在对来自性传播疾病诊所的HIV-1血清阳性和HIV-1血清阴性的乌干达成年成对样本的研究中，对唾液人类1型免疫缺陷病毒（HIV-1）抗体检测的准确性和可接受性进行了比较。唾液收集是通过Omni-sal设备（Saliva Diagnostic Systems，温哥华，华盛顿）进行的，抗体测试是通过快速滤纸测定法（Test-Pack; Abbott实验室，Abbott Park，伊利诺伊州）进行的。相对于血清测试，唾液测试的灵敏度为95％（205个中的195个），特异性为99％（297个中的295个）。血清中β-2微球蛋白水平升高且HIV-1相关症状增多的患者，唾液检测的敏感性更高。研究前和研究后的访谈表明，唾液检测并没有加剧对唾液暴露的过分恐惧。需要开发廉价且不需要电力的唾液测试。

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