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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Lymphocyte Modulation in a Baboon Model of Immunosenescence
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Lymphocyte Modulation in a Baboon Model of Immunosenescence

机译：狒狒模型中的免疫调节的淋巴细胞。

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The age-related modulation of lymphocyte number and function was assessed in a nonhuman primate model consisting of healthy olive baboons (Papio cynocephalus anubis) of ages encompassing the entire life span of this species. The objectives of this study were to characterize an animal model of immunosenescence and to assess whether or not age should be considered when designing studies for the evaluation of vaccine candidates in baboons. Specifically the following parameters were assessed in baboons from 6 months to 26 years of age: relative numbers of B lymphocytes, CD4+ and CD8+ T lymphocytes, and T lymphocytes expressing CD28, CD25, and phytohemagglutinin-stimulated lymphoproliferative activity; and concentrations of total immunoglobulin, soluble interleukin-2 receptor α, and soluble CD30 in serum. There was a statistically significant effect of age on lymphocyte numbers. As age increased, relative B-cell numbers (ranging from 6 to 50%) decreased (P < 0.001) and relative T-cell numbers (ranging from 28 to 80%) increased (P < 0.001). The increase in T-cell numbers involved both the CD4+ and CD8+ subsets. In addition, there was a significant negative correlation of age with levels of soluble interleukin-2 receptor α in serum. Modulation of lymphocyte numbers appears to occur gradually during the entire baboon life span, thus suggesting the presence of an age-related developmentally regulated process. These findings indicate that baboons represent a potentially useful model to study selected phenomena related to immunosenescence. These findings also indicate that, when using the baboon model for vaccine or other experimental protocols requiring the assessment of immune responses, it would be appropriate to take into account the age of the animals in the study design.
机译：在一个非人类的灵长类动物模型中评估了与年龄相关的淋巴细胞数量和功能调节，该模型由健康的狒狒（Papio cynocephalus anubis ）组成，涵盖该物种的整个寿命。这项研究的目的是表征免疫衰老的动物模型，并评估在设计评估狒狒候选疫苗的研究时是否应考虑年龄。具体而言，在6个月至26岁的狒狒中评估了以下参数：B淋巴细胞，CD4 + 和CD8 + T淋巴细胞以及表达CD28的T淋巴细胞的相对数量，CD25和植物血凝素刺激的淋巴增生活性;血清中总免疫球蛋白，可溶性白介素2受体α和可溶性CD30的浓度。年龄对淋巴细胞数量有统计学上的显着影响。随着年龄的增长，相对B细胞数量（从6％到50％）减少（ P <0.001），相对T细胞数量（从28％到80％）增加（ P <0.001）。 T细胞数量的增加涉及CD4 + 和CD8 + 子集。此外，年龄与血清中可溶性白介素2受体α水平呈显着负相关。淋巴细胞数量的调节似乎在整个狒狒的整个生命周期中逐渐发生，因此表明存在与年龄相关的发育调节过程。这些发现表明，狒狒代表了研究与免疫衰老相关的特定现象的潜在有用模型。这些发现还表明，当将狒狒模型用于疫苗或其他需要评估免疫反应的实验方案时，在研究设计中考虑动物的年龄将是适当的。

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